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Multiomic approaches to stroke: the beginning of a journey.

作者信息

Debette Stéphanie, Chasman Daniel I

机构信息

University of Bordeaux, INSERM U1219, Bordeaux Population Health (BPH) Research Center, Bordeaux, France.

Bordeaux University Hospital, Department of Neurology, Institute for Neurodegenerative Diseases, Bordeaux, France.

出版信息

Nat Rev Neurol. 2024 Feb;20(2):65-66. doi: 10.1038/s41582-023-00908-w.

DOI:10.1038/s41582-023-00908-w

PMID:38102384

Abstract

摘要

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Multiomic approaches to stroke: the beginning of a journey.

作者信息

Debette Stéphanie, Chasman Daniel I

机构信息

University of Bordeaux, INSERM U1219, Bordeaux Population Health (BPH) Research Center, Bordeaux, France.

Bordeaux University Hospital, Department of Neurology, Institute for Neurodegenerative Diseases, Bordeaux, France.

出版信息

Nat Rev Neurol. 2024 Feb;20(2):65-66. doi: 10.1038/s41582-023-00908-w.

DOI:10.1038/s41582-023-00908-w

PMID:38102384

Abstract

摘要

相似文献

Multiomic approaches to stroke: the beginning of a journey.

Nat Rev Neurol. 2024 Feb;20(2):65-66. doi: 10.1038/s41582-023-00908-w.

Towards multiomic analysis of oral mucosal pathologies.

Semin Immunopathol. 2023 Jan;45(1):111-123. doi: 10.1007/s00281-022-00982-0. Epub 2023 Feb 15.

EmptyDropsMultiome discriminates real cells from background in single-cell multiomics assays.

Genome Biol. 2024 May 13;25(1):121. doi: 10.1186/s13059-024-03259-x.

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Pediatr Res. 2023 Jan;93(2):308-315. doi: 10.1038/s41390-022-02181-x. Epub 2022 Jul 8.

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Allergy. 2023 Oct;78(10):2802-2804. doi: 10.1111/all.15770. Epub 2023 May 22.

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Curr Opin HIV AIDS. 2023 Sep 1;18(5):246-256. doi: 10.1097/COH.0000000000000809. Epub 2023 Jul 17.

BaySyn: Bayesian Evidence Synthesis for Multi-system Multiomic Integration.

Pac Symp Biocomput. 2023;28:275-286.

Single-cell multiomic analyses sheds light on mitochondrial mutational selection.

Nat Genet. 2023 Jul;55(7):1083-1085. doi: 10.1038/s41588-023-01436-5.

Probabilistic tensor decomposition extracts better latent embeddings from single-cell multiomic data.

Nucleic Acids Res. 2023 Aug 25;51(15):e81. doi: 10.1093/nar/gkad570.

Multiomic signatures of body mass index identify heterogeneous health phenotypes and responses to a lifestyle intervention.

Nat Med. 2023 Apr;29(4):996-1008. doi: 10.1038/s41591-023-02248-0. Epub 2023 Mar 20.

引用本文的文献

Integrative Multi-Omics Analysis for Etiology Classification and Biomarker Discovery in Stroke: Advancing towards Precision Medicine.

Biology (Basel). 2024 May 13;13(5):338. doi: 10.3390/biology13050338.

本文引用的文献

A large-scale microRNA transcriptome-wide association study identifies two susceptibility microRNAs, miR-1307-5p and miR-192-3p, for colorectal cancer risk.

Hum Mol Genet. 2024 Feb 1;33(4):333-341. doi: 10.1093/hmg/ddad185.

Genetic support for FDA-approved drugs over the past decade.

Nat Rev Drug Discov. 2023 Nov;22(11):864. doi: 10.1038/d41573-023-00158-x.

Leveraging polygenic enrichments of gene features to predict genes underlying complex traits and diseases.

Nat Genet. 2023 Aug;55(8):1267-1276. doi: 10.1038/s41588-023-01443-6. Epub 2023 Jul 13.

Hallmarks of neurodegenerative diseases.

Cell. 2023 Feb 16;186(4):693-714. doi: 10.1016/j.cell.2022.12.032.

Stroke genetics informs drug discovery and risk prediction across ancestries.

Nature. 2022 Nov;611(7934):115-123. doi: 10.1038/s41586-022-05165-3. Epub 2022 Sep 30.

Stroke-associated intergenic variants modulate a human FOXF2 transcriptional enhancer.

Proc Natl Acad Sci U S A. 2022 Aug 30;119(35):e2121333119. doi: 10.1073/pnas.2121333119. Epub 2022 Aug 22.

Integration of genetically regulated gene expression and pharmacological library provides therapeutic drug candidates.

Hum Mol Genet. 2021 Apr 26;30(3-4):294-304. doi: 10.1093/hmg/ddab049.

Multilevel omics for the discovery of biomarkers and therapeutic targets for stroke.

Nat Rev Neurol. 2020 May;16(5):247-264. doi: 10.1038/s41582-020-0350-6. Epub 2020 Apr 22.

TMEM16A Inhibition Preserves Blood-Brain Barrier Integrity After Ischemic Stroke.

Front Cell Neurosci. 2019 Aug 6;13:360. doi: 10.3389/fncel.2019.00360. eCollection 2019.

Integrating functional data to prioritize causal variants in statistical fine-mapping studies.

PLoS Genet. 2014 Oct 30;10(10):e1004722. doi: 10.1371/journal.pgen.1004722. eCollection 2014 Oct.