Department of Dermatology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province, China.
Department of Obstetrics and Gynaecology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province, China.
J Int Med Res. 2023 Dec;51(12):3000605231217950. doi: 10.1177/03000605231217950.
Impetigo herpetiformis is a rare skin disease that most often occurs in the third trimester of pregnancy. It is currently considered as a form of generalized pustular psoriasis and the typical skin lesions comprise small sterile pustules. Here, a case of impetigo herpetiformis in the second trimester of pregnancy after 7 weeks of hydroxychloroquine administration for suspected Sjogren's syndrome is reported. Treatment with anti-infective, anti-inflammatory and immunosuppressive medication did not improve the patient's condition. Following delivery of a live male by emergency caesarean section at 29 weeks' gestation, the rash was reported to be completely resolved by 3 months postpartum. Previously published cases of impetigo herpetiformis in the second trimester of pregnancy that were retrieved from a search of the PubMed database are also reviewed and discussed.
疱疹样脓疱病是一种罕见的皮肤病，多发生于妊娠晚期。目前认为其是泛发性脓疱型银屑病的一种特殊类型，典型的皮肤损害为小的无菌脓疱。本文报道了一例疑似干燥综合征患者在接受羟氯喹治疗 7 周后于妊娠中期（孕 2 个月）出现疱疹样脓疱病。给予抗感染、抗炎和免疫抑制药物治疗后，患者病情未见改善。孕 29 周时，患者因“急症剖宫产”娩出一名活男婴，皮疹于产后 3 个月完全消退。此外，还对从 PubMed 数据库检索到的妊娠中期疱疹样脓疱病的相关病例进行了复习和讨论。
