Department of Health Services Management, Guizhou Medical University, Guiyang, China.
Center of Medicine Economics and Management Research, Guizhou Medical University, Guiyang, China.
Eur J Health Econ. 2024 Sep;25(7):1087-1094. doi: 10.1007/s10198-023-01647-x. Epub 2023 Dec 17.
The composite time trade-off (cTTO) method is used as the primary method for valuing EQ-5D-5L health states, but it requires intensive interviewer training and stringent quality control, which increases the burden of conducting cTTO studies. In this study, two non-iterative variants of the TTO method, non-stopping TTO (nTTO) and open-ended TTO (oTTO), were tested head-to-head with the cTTO method aiming to reduce the administration burden.
31 EQ-5D-5L health states from an orthogonal array was selected and valued by a general public sample in China. Data were collected by 7 interviewers with all interviewers performed an equal number of interviews using all three TTO methods. We compared the value distribution, logical consistency, administration burden, and modeling performance of these three TTO methods.
In total, 422 participants participated in the valuation interviews, with 139 using the nTTO method, 140 using the oTTO method, and 143 using the cTTO method. Both oTTO and nTTO methods saved around 10 min for conducting an interview. The mean values of three methods were similar with each method showed different characteristics in their value distributions. cTTO outperformed the other two methods in terms of modeling performance.
Both non-iterative TTO methods showed potential for valuing EQ-5D health states, although their data distributions and modeling performance were inferior to the cTTO method. The results of this study showed the potential of these two alternative non-iterative TTO methods.
复合时间权衡（cTTO）方法被用作评估 EQ-5D-5L 健康状态的主要方法，但它需要密集的访谈者培训和严格的质量控制，这增加了进行 cTTO 研究的负担。在这项研究中，我们对头对头测试了 TTO 方法的两个非迭代变体，即非停止 TTO（nTTO）和开放式 TTO（oTTO），旨在减轻管理负担。
从正交数组中选择 31 个 EQ-5D-5L 健康状态，并由中国普通公众样本进行评估。数据由 7 名访谈者收集，所有访谈者使用所有三种 TTO 方法进行了相等数量的访谈。我们比较了这三种 TTO 方法的价值分布、逻辑一致性、管理负担和建模性能。
共有 422 名参与者参加了价值评估访谈，其中 139 名使用 nTTO 方法，140 名使用 oTTO 方法，143 名使用 cTTO 方法。oTTO 和 nTTO 方法在进行一次访谈时都节省了大约 10 分钟。三种方法的平均值相似，每种方法在价值分布上都表现出不同的特点。cTTO 在建模性能方面优于其他两种方法。
两种非迭代 TTO 方法都显示出了评估 EQ-5D 健康状态的潜力，尽管它们的数据分布和建模性能逊于 cTTO 方法。本研究的结果显示了这两种替代的非迭代 TTO 方法的潜力。
