用于可视化和选择性杀死乳腺癌细胞的NQO-1可激活近红外光敏剂。
NQO-1 activatable NIR photosensitizer for visualization and selective killing of breast cancer cells.
作者信息
Li Zhipeng, Feng Qincong, Hou Jiting, Shen Jianliang
机构信息
National Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.
National Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.
出版信息
Bioorg Chem. 2024 Feb;143:107021. doi: 10.1016/j.bioorg.2023.107021. Epub 2023 Dec 9.
The diagnosis and treatment of breast cancer is of immense importance in improving patient outcomes. The biological marker NAD(P)H:quinone oxidoreductase 1 was utilized to design BrCyS-Q, a near-infrared activatable photosensitizer for breast cancer. BrCyS-Q was successfully employed to diagnose breast cancer cells using fluorescence and photodynamic inhibition. The findings of this research may offer novel insights for the diagnosis and treatment of clinical breast cancer via photodynamic therapy.
乳腺癌的诊断和治疗对于改善患者预后至关重要。利用生物标志物烟酰胺腺嘌呤二核苷酸（磷酸）：醌氧化还原酶1设计了BrCyS-Q，一种用于乳腺癌的近红外可激活光敏剂。BrCyS-Q已成功用于通过荧光和光动力抑制来诊断乳腺癌细胞。本研究结果可能为通过光动力疗法对临床乳腺癌进行诊断和治疗提供新的见解。
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