Bae Heewon, Kang Min Ju, Ha Sang-Won, Jeong Da-Eun, Lee Kiwon, Lim Seungui, Min Jin-Young, Min Kyoung-Bok
Veterans Medical Research Institute, Veterans Health Service Medical Center, Seoul, Republic of Korea.
Department of Clinical Research Design and Evaluation, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Seoul, Republic of Korea.
Front Aging Neurosci. 2023 Dec 1;15:1291881. doi: 10.3389/fnagi.2023.1291881. eCollection 2023.
Oligomeric Aβ (OAβ) is a promising candidate marker for Alzheimer's disease (AD) diagnosis. Electroencephalography (EEG) is a potential tool for early detection of AD. Still, whether EEG power ratios, particularly the theta/alpha ratio (TAR) and theta/beta ratio (TBR), reflect Aβ burden-a primary mechanism underlying cognitive impairment and AD. This study investigated the association of TAR and TBR with amyloid burden in older adults based on MDS-OAβ levels.
529 individuals (aged ≥60 years) were recruited. All participants underwent EEG (MINDD SCAN, Ybrain Inc., South Korea) and AlzOn™ test (PeopleBio Inc., Gyeonggi-do, Republic of Korea) for quantifying MDS-OAβ values in the plasma. EEG variables were log-transformed to normalize the data distribution. Using the MDS-OAβ cutoff value (0.78 ng/mL), all participants were classified into two groups: high MDS-OAβ and low MDS-OAβ.
Participants with high MDS-OAβ levels had significantly higher TARs and TBRs than those with low MDS-OAβ levels. The log-transformed TBRs in the central lobe (β = 0.161, = 0.0026), frontal lobe (β = 0.145, = 0.0044), parietal lobe (β = 0.166, = 0.0028), occipital lobe (β = 0.158, = 0.0058), and temporal lobe (beta = 0.162, = 0.0042) were significantly and positively associated with increases in MDS-OAβ levels. After adjusting for the Bonferroni correction, the TBRs in all lobe regions, except the occipital lobe, were significantly associated with increased MDS-OAβ levels.
We found a significant association of MDS-OAβ with TBR in older adults. This finding indicates that an increase in amyloid burden may be associated with an increase in the low-frequency band and a decrease in the relatively high-frequency band.
寡聚β淀粉样蛋白（OAβ）是阿尔茨海默病（AD）诊断中一个很有前景的候选标志物。脑电图（EEG）是早期检测AD的一种潜在工具。然而，EEG功率比，特别是θ/α比值（TAR）和θ/β比值（TBR）是否反映β淀粉样蛋白负担——认知障碍和AD的一个主要潜在机制。本研究基于MDS - OAβ水平调查了老年人中TAR和TBR与淀粉样蛋白负担的关联。
招募了529名个体（年龄≥60岁）。所有参与者均接受了脑电图检查（MINDD SCAN，韩国Ybrain公司）和AlzOn™检测（韩国京畿道PeopleBio公司），以定量血浆中的MDS - OAβ值。对EEG变量进行对数转换以标准化数据分布。使用MDS - OAβ临界值（0.78 ng/mL），将所有参与者分为两组：高MDS - OAβ组和低MDS - OAβ组。
MDS - OAβ水平高的参与者的TAR和TBR显著高于MDS - OAβ水平低的参与者。中央叶（β = 0.161，P = 0.0026）、额叶（β = 0.145，P = 0.0044）、顶叶（β = 0.166，P = 0.0028）、枕叶（β = 0.158，P = 0.0058）和颞叶（β = 0.162，P = 0.0042）的对数转换后的TBR与MDS - OAβ水平的升高显著正相关。在进行Bonferroni校正后，除枕叶外，所有叶区域的TBR均与MDS - OAβ水平升高显著相关。
我们发现老年人中MDS - OAβ与TBR之间存在显著关联。这一发现表明淀粉样蛋白负担的增加可能与低频带的增加和相对高频带的减少有关。
