连续流动条件下缩醛胺的制备。
Preparation of Aminals under Continuous Flow Conditions.
作者信息
Gomes Rafael F A, Afonso Carlos A M
机构信息
Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Avenida Professor Gama Pinto, 1649-003 Lisbon, Portugal.
出版信息
J Chem Educ. 2023 Nov 17;100(12):4728-4733. doi: 10.1021/acs.jchemed.3c00306. eCollection 2023 Dec 12.
A laboratory experiment was developed for the continuous flow preparation of an aminal derived from the condensation of furfural with morpholine. The experiment introduces the students to concepts of green chemistry, heterogeneous catalysis, and continuous flow. A cheap and easy setup allows the heterogeneous catalyst reactor to be built in class. The use of furfural reinforces the importance of green chemistry by using one of the key synthons obtained from biomass.
开发了一种实验室实验，用于连续流制备由糠醛与吗啉缩合得到的胺。该实验向学生介绍了绿色化学、多相催化和连续流的概念。一个廉价且简易的装置使得可以在课堂上搭建多相催化反应器。糠醛的使用通过利用从生物质中获得的关键合成子之一，强化了绿色化学的重要性。
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