Interdisciplinary Scientist Training Program, University of Chicago Pritzker School of Medicine, Chicago, IL, United States of America.
Committee on Computational Neuroscience, University of Chicago, Chicago, IL, United States of America.
PLoS One. 2023 Dec 18;18(12):e0295140. doi: 10.1371/journal.pone.0295140. eCollection 2023.
When multiple stimuli appear together in the receptive field of a visual cortical neuron, the response is typically close to the average of that neuron's response to each individual stimulus. The departure from a linear sum of each individual response is referred to as normalization. In mammals, normalization has been best characterized in the visual cortex of macaques and cats. Here we study visually evoked normalization in the visual cortex of awake mice using imaging of calcium indicators in large populations of layer 2/3 (L2/3) V1 excitatory neurons and electrophysiological recordings across layers in V1. Regardless of recording method, mouse visual cortical neurons exhibit normalization to varying degrees. The distributions of normalization strength are similar to those described in cats and macaques, albeit slightly weaker on average.
当多个刺激同时出现在视觉皮层神经元的感受野中时,其反应通常接近该神经元对每个单独刺激的反应的平均值。这种与每个单独反应的线性和的偏差被称为归一化。在哺乳动物中,归一化在猕猴和猫的视觉皮层中得到了最好的描述。在这里,我们使用钙指示剂在大群体的层 2/3 (L2/3) V1 兴奋性神经元中的成像和在 V1 中跨层的电生理记录来研究清醒小鼠的视觉诱发归一化。无论采用哪种记录方法,小鼠视觉皮层神经元都表现出不同程度的归一化。归一化强度的分布与在猫和猕猴中描述的相似,尽管平均强度略弱。