Department of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
Systems Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Neuron. 2018 Apr 18;98(2):256-281. doi: 10.1016/j.neuron.2018.03.040.
Tremendous progress has been made since Neuron published our Primer on genetic dissection of neural circuits 10 years ago. Since then, cell-type-specific anatomical, neurophysiological, and perturbation studies have been carried out in a multitude of invertebrate and vertebrate organisms, linking neurons and circuits to behavioral functions. New methods allow systematic classification of cell types and provide genetic access to diverse neuronal types for studies of connectivity and neural coding during behavior. Here we evaluate key advances over the past decade and discuss future directions.
自神经元发表我们关于神经回路遗传解析的入门指南 10 年前以来，已经取得了巨大的进展。此后，在许多无脊椎动物和脊椎动物中进行了细胞类型特异性的解剖、神经生理学和干扰研究，将神经元和回路与行为功能联系起来。新方法允许对细胞类型进行系统分类，并为研究行为期间的连接和神经编码提供对各种神经元类型的遗传访问。在这里，我们评估过去十年的关键进展，并讨论未来的方向。
