Amato Valdir Sabbaga, Franco Lucas Augusto Moyses, de Souza Regina Maia, da Silva Camila Alves Maia, Ramundo Mariana Severo, Côrtes Marina Farrel, Corrêa-Castro Gabriela, Santos-Oliveira Joanna Reis, Da-Cruz Alda M, Pagliari Carla, Galo Luciane Kanashiro, Tuon Felipe Francisco
Universidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical, Laboratório de Parasitologia, São Paulo, Brazil.
Universidade de São Paulo, Faculdade de Medicina, Departamento de Doenças e Moléstias Infecciosas, São Paulo, Brazil.
Am J Trop Med Hyg. 2023 Dec 18;110(2):228-233. doi: 10.4269/ajtmh.23-0287. Print 2024 Feb 7.
In situ and systemic evaluations of the immune responses of HIV-infected patients to mucosal leishmaniasis have been poorly described. We describe a recently diagnosed HIV-infected patient with mucosal leishmaniasis who was characterized by a CD4 count of 85 cells/mm3 and nasal septum destruction resulting from pruritic and ulcerated nasal mucosa with crust formation and progression over 2 years. In situ and systemic immune evaluations of T cell activation, memory, and exhaustion were conducted using cytofluorometric assays, and sequencing of the Leishmania species was performed. The immune profile of HIV-infected patient with mucosal leishmaniasis shows a mixed Th1/Th2 pattern and an activated and exhausted status.
对HIV感染患者针对黏膜利什曼病的免疫反应进行的原位和全身评估描述甚少。我们描述了一名近期诊断为HIV感染且患有黏膜利什曼病的患者，其特征为CD4细胞计数为85个/立方毫米，鼻中隔因瘙痒性和溃疡性鼻黏膜伴结痂形成而遭到破坏，并在2年中不断进展。使用细胞荧光分析对T细胞活化、记忆和耗竭进行了原位和全身免疫评估，并对利什曼原虫物种进行了测序。感染HIV且患有黏膜利什曼病的患者的免疫特征显示出Th1/Th2混合模式以及活化和耗竭状态。
