Kanwal Tehreem, Rasheed Sufian, Hassan Mahjabeen, Fatima Batool, Xiao Hua-Ming, Musharraf Syed Ghulam, Najam-Ul-Haq Muhammad, Hussain Dilshad
HEJ Research Institute of Chemistry, International Center for Chemical and Biological Science (ICCBS), University of Karachi, Karachi 75270 Pakistan.
Department of Biochemistry, Bahauddin Zakariya University, Multan 60800, Pakistan.
ACS Appl Mater Interfaces. 2024 Jan 10;16(1):1688-1704. doi: 10.1021/acsami.3c12565. Epub 2023 Dec 18.
Fluorescent metal-organic frameworks (MOFs) are promising sensing materials with tunable and robust structural properties and remarkable luminescent capabilities. In this study, a novel dual-emission fluorescent metal-organic framework (EY@MOF-5) composite is synthesized by a one-pot bottle-around-ship approach. Eosin Y (EY) is encapsulated in MOF-5 to enhance its fluorescence properties and selectivity, effectively addressing typical MOF-5 limitations. EY@MOF-5 serves as a versatile dual-functional fluorescent sensor for two different analytes, daclatasvir (DCT) and nitenpyram (NTP), showing an impressive linear range of 10-200 nM and 0.1-300 μM, with detection limits of 233 pM and 65 nM, respectively. The established method is ultrafast, highly sensitive, and extremely selective for DCT and NTP detection in complex biological and food samples. Fluorescence results are compared and validated with the recommended UPLC method. Then, a smartphone-integrated sensing system is introduced for on-site, real-time, and quantitative analysis of DCT and NTP. The smartphone-assisted intelligent sensing method manifests promising results for DCT and NTP monitoring in biological and food samples, demonstrating its promising potential for the on-site detection of biologically and environmentally significant analytes.
荧光金属有机框架材料（MOFs）是一类很有前景的传感材料，具有可调节且稳定的结构特性以及出色的发光能力。在本研究中，通过一锅法“瓶中船”策略合成了一种新型的双发射荧光金属有机框架复合材料（EY@MOF-5）。将曙红Y（EY）封装在MOF-5中以增强其荧光特性和选择性，有效解决了典型的MOF-5局限性。EY@MOF-5作为一种通用的双功能荧光传感器，可用于检测两种不同的分析物，即达卡他韦（DCT）和烯啶虫胺（NTP），其线性范围分别为10 - 200 nM和0.1 - 300 μM，检测限分别为233 pM和65 nM。所建立的方法对于复杂生物和食品样品中的DCT和NTP检测具有超快速、高灵敏度和极高选择性。将荧光结果与推荐的超高效液相色谱法进行比较和验证。然后，引入了一种集成智能手机的传感系统，用于对DCT和NTP进行现场、实时和定量分析。这种智能手机辅助的智能传感方法在生物和食品样品中对DCT和NTP监测显示出有前景的结果，证明了其在现场检测生物和环境中重要分析物方面的潜在应用价值。
