功能性胆囊疾病：一项前瞻性队列研究的中期分析。
Functional gallbladder disorder: Interim analysis of a prospective cohort study.
机构信息
Department of Surgery, Ascension Saint Agnes Hospital, Baltimore, MD, 21229, USA.
Department of Surgery, Ascension Saint Agnes Hospital, Baltimore, MD, 21229, USA.
出版信息
Am J Surg. 2024 Mar;229:129-132. doi: 10.1016/j.amjsurg.2023.12.010. Epub 2023 Dec 13.
BACKGROUND
Functional gallbladder disorder (FGBD) remains a controversial indication for cholecystectomy.
METHODS
A prospective cohort study enrolled patients strictly meeting Rome criteria for FGBD, and cholecystectomy was performed. They were assessed pre- and 3 and 6 months postoperatively with surveys of abdominal pain and quality of life (RAPID and SF-12 surveys, respectively). Interim analysis was performed.
RESULTS
Although neither ejection fraction nor pain reproduction predicted success after cholecystectomy, the vast majority of enrolled patients had a successful outcome after undergoing cholecystectomy for FGBD: of a planned 100 patients, 46 were enrolled. Of 31 evaluable patients, 26 (83.9 %) reported RAPID improvement and 28 (93.3 %) SF12 improvement at 3- or 6-month follow-up.
CONCLUSION
FGBD, strictly diagnosed, should perhaps no longer be a controversial indication for cholecystectomy, since its success rate for biliary pain in this study was similar to that for symptomatic cholelithiasis. Larger-scale studies or randomized trials may confirm these findings.
背景
功能性胆囊疾病（FGBD）仍然是胆囊切除术有争议的适应证。
方法
一项前瞻性队列研究纳入了严格符合 FGBD 罗马标准的患者，并进行了胆囊切除术。他们在术前和术后 3 个月和 6 个月分别使用腹部疼痛和生活质量调查（RAPID 和 SF-12 调查）进行评估。进行了中期分析。
结果
尽管射血分数或疼痛再现均不能预测胆囊切除术后的成功，但大多数接受 FGBD 胆囊切除术的患者都取得了成功的结果：计划入组 100 例患者，实际入组 46 例。31 例可评估的患者中，26 例（83.9%）报告 RAPID 在 3 或 6 个月随访时有所改善，28 例（93.3%）SF12 有所改善。
结论
严格诊断的 FGBD 可能不再是胆囊切除术有争议的适应证，因为本研究中胆囊切除术治疗胆绞痛的成功率与症状性胆石症相似。更大规模的研究或随机试验可能会证实这些发现。
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