尿液与结石分析的关键要点。医源性尿路结石的外观。

Critical aspects of urine and stone analysis. Appearance of iatrogenic urinary calculi.

作者信息

Asper R, Schmucki O

出版信息

Urol Int. 1986;41(5):334-42. doi: 10.1159/000281233.

Abstract

In 25% of the samples the often applied qualitative chemical analysis of urinary stones leads to entirely wrong results with severe therapeutic consequences. The appropriate techniques for stone analysis are infrared spectroscopy and X-ray powder diffraction. These techniques make also possible the identification of iatrogenic urinary calculi. Four types of such stones were detected here, caused by modern medication. N4-acetylsulfamethoxazole, N4-acetylsulfadiazine, mefenamic acid and silicon dioxide. It is only the correct preanalytical treatment of urine samples that prevents considerable impairment of analytical results. Without precautions especially, the oxalate concentration in urine may be doubled or tripled during one day of storage.

摘要

在25%的样本中，常用的尿结石定性化学分析会得出完全错误的结果，从而导致严重的治疗后果。结石分析的合适技术是红外光谱法和X射线粉末衍射法。这些技术还能够识别医源性尿路结石。此处检测到了由现代药物引起的四种此类结石。N4-乙酰磺胺甲恶唑、N4-乙酰磺胺嘧啶、甲芬那酸和二氧化硅。只有对尿液样本进行正确的分析前处理，才能防止分析结果受到严重影响。特别是如果不采取预防措施，尿液中的草酸盐浓度在储存一天期间可能会增加一倍或两倍。