Ebisuno S, Morimoto S, Yoshida T, Fukatani T, Yasukawa S, Okawa T
Hinyokika Kiyo. 1986 Dec;32(12):1773-9.
Oral oxalate loading using sodium oxalate or a vegetable juice was done to evaluate the intestinal absorption of exogenous oxalate in 30 patients with renal stones and 13 healthy controls. Fifteen calcium oxalate stone formers, 7 non-oxalate stone formers and 10 healthy volunteers were given an oral loading of sodium oxalate (500 mg). Urinary oxalate increased promptly, reaching a peak value within 4 to 8 hours after administration of a synthetic oxalate orally in a fasting state. In calcium oxalate stone formers, the mean increment of urinary oxalate and the bioavailability following oral sodium oxalate load were significantly higher than in the healthy controls and non-oxalate stone formers. Furthermore, intestinal hyperabsorption of oxalate in our criterion was defined in six patients with calcium oxalate stones (40%). On the other hand, eight calcium oxalate stone formers and three healthy controls were given vegetable juice. Urinary oxalate was increased only slightly after the ingestion, and there was no difference between calcium oxalate stone formers and normal controls. These results suggest that a certain hyperoxaluria might be induced by intestinal absorption of exogenous oxalate, and that the hyperabsorption might indicate a possible risk factor for calcium oxalate stone formation.
采用草酸钠或蔬菜汁进行口服草酸盐负荷试验，以评估30例肾结石患者和13名健康对照者对外源性草酸盐的肠道吸收情况。给15例草酸钙结石形成者、7例非草酸盐结石形成者和10名健康志愿者口服草酸钠（500毫克）。在空腹状态下口服合成草酸盐后，尿草酸盐迅速增加，在给药后4至8小时内达到峰值。在草酸钙结石形成者中，口服草酸钠负荷后尿草酸盐的平均增量和生物利用度显著高于健康对照者和非草酸盐结石形成者。此外，按照我们的标准，6例草酸钙结石患者（40%）存在肠道草酸盐过度吸收。另一方面，给8例草酸钙结石形成者和3名健康对照者饮用蔬菜汁。摄入后尿草酸盐仅略有增加，草酸钙结石形成者与正常对照者之间无差异。这些结果表明，肠道吸收外源性草酸盐可能会诱发一定程度的高草酸尿症，且这种过度吸收可能是草酸钙结石形成的一个潜在危险因素。
