Department of Hepatology and Gastroenterology, Aarhus University Hospital Skejby, Aarhus, Denmark
Department of Pathology, Aarhus University Hospital Skejby, Aarhus N, Denmark.
BMJ Case Rep. 2023 Dec 18;16(12):e257569. doi: 10.1136/bcr-2023-257569.
A man presents a 4 mm skin tumour at his general practitioner. The tumour is removed on the suspicion of a dermatofibroma. Important differential diagnoses are sebaceous neoplasms, melanomas, Merkel cell carcinomas and large cell neuroendocrine carcinoma, and metastases of neuroendocrine neoplasms from the gut or lung. Immunohistochemical staining excluded sebaceous neoplasm, melanoma and Merkel cell carcinoma, however, was positive for multiple neuroendocrine markers. Relevant scans showed no signs of a primary tumour anywhere else. The final diagnosis was a primary low-grade neuroendocrine carcinoma of the skin. At 30 months follow-up, there was no sign of recurrence.
一位男性在全科医生处就诊时，呈现出一个 4 毫米的皮肤肿瘤。由于怀疑是皮肤纤维瘤，该肿瘤被切除。需要鉴别的重要疾病包括皮脂腺肿瘤、黑色素瘤、默克尔细胞癌和大细胞神经内分泌癌，以及胃肠道或肺部神经内分泌肿瘤的转移。免疫组织化学染色排除了皮脂腺肿瘤、黑色素瘤和默克尔细胞癌，但对多种神经内分泌标志物呈阳性。相关扫描未显示其他任何部位的原发性肿瘤迹象。最终诊断为皮肤原发性低度神经内分泌癌。在 30 个月的随访中，没有复发的迹象。
