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产妇严重不良结局终生发病风险:一种新的孕产妇健康指标。

Lifetime risk of maternal near miss morbidity: a novel indicator of maternal health.

机构信息

Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.

Department of Population Health, London School of Hygiene and Tropical Medicine, London, UK.

出版信息

Int J Epidemiol. 2024 Feb 1;53(1). doi: 10.1093/ije/dyad169.

Abstract

BACKGROUND

The lifetime risk of maternal death quantifies the probability that a 15-year-old girl will die of a maternal cause in her reproductive lifetime. Its intuitive appeal means it is a widely used summary measure for advocacy and international comparisons of maternal health. However, relative to mortality, women are at an even higher risk of experiencing life-threatening maternal morbidity called 'maternal near miss' (MNM) events-complications so severe that women almost die. As maternal mortality continues to decline, health indicators that include information on both fatal and non-fatal maternal outcomes are required.

METHODS

We propose a novel measure-the lifetime risk of MNM-to estimate the cumulative risk that a 15-year-old girl will experience a MNM in her reproductive lifetime, accounting for mortality between the ages 15 and 49 years. We apply the method to the case of Namibia (2019) using estimates of fertility and survival from the United Nations World Population Prospects along with nationally representative data on the MNM ratio.

RESULTS

We estimate a lifetime risk of MNM in Namibia in 2019 of between 1 in 40 and 1 in 35 when age-disaggregated MNM data are used, and 1 in 38 when a summary estimate for ages 15-49 years is used. This compares to a lifetime risk of maternal death of 1 in 142 and yields a lifetime risk of severe maternal outcome (MNM or death) of 1 in 30.

CONCLUSIONS

The lifetime risk of MNM is an urgently needed indicator of maternal morbidity because existing measures (the MNM ratio or rate) do not capture the cumulative risk over the reproductive life course, accounting for fertility and mortality levels.

摘要

背景

孕产妇死亡终身风险量化了一名 15 岁少女在其生殖期内死于孕产妇原因的概率。由于其直观的吸引力,它是一个广泛用于倡导和国际比较孕产妇健康的汇总指标。然而,与死亡率相比,女性面临更高的风险,即经历危及生命的孕产妇发病率,称为“孕产妇接近死亡”(maternal near miss,MNM)事件——严重到女性几乎死亡的并发症。随着孕产妇死亡率持续下降,需要包括致命和非致命孕产妇结局信息在内的健康指标。

方法

我们提出了一种新的衡量标准——MNM 终身风险,以估计一名 15 岁少女在其生殖期内经历 MNM 的累积风险,同时考虑到 15 至 49 岁之间的死亡率。我们使用联合国世界人口展望中的生育率和生存率估计值以及关于 MNM 比值的全国代表性数据,对纳米比亚(2019 年)的情况应用该方法。

结果

当使用按年龄细分的 MNM 数据时,我们估计 2019 年纳米比亚的 MNM 终身风险在 1/40 到 1/35 之间,当使用 15-49 岁年龄综合估计值时,该风险为 1/38。这与孕产妇死亡终身风险 1/142 相比,导致严重孕产妇结局(MNM 或死亡)终身风险 1/30。

结论

MNM 终身风险是孕产妇发病率急需的指标,因为现有指标(MNM 比值或率)无法捕捉生殖期内的累积风险,同时考虑到生育率和死亡率水平。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95dc/11212495/97b5f6bb4188/dyad169f1.jpg

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