Hematology, Oncology, Transplant Program, Alberta Children's Hospital, Calgary, Alberta, Canada.
Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Pediatr Blood Cancer. 2024 Mar;71(3):e30807. doi: 10.1002/pbc.30807. Epub 2023 Dec 18.
Children with sickle cell disease (SCD) are at risk for physical, psychological, and social adjustment challenges. This study sought to investigate social adjustment and related factors in children living with SCD.
Data from 32 children (50% male, mean age = 10.32 years, SD = 3.27) were retrospectively collected from a neuropsychology clinic at a tertiary care pediatric hospital. Social adjustment was measured using the Behavior Assessment System for Children (BASC-3) parent-proxy, withdrawal subscale, and the Pediatric Quality of Life Inventory (PedsQL) Generic Module Social Functioning self- and parent-proxy subscales. Other measures captured executive functioning (i.e., Behavior Rating Inventory of Executive Function, Second Edition (BRIEF-2) Parent Form) and non-disease-related associations with social adjustment, including number of years in Canada and family functioning (i.e., PedsQL Family Impact Module).
Sixteen percent of patients reported elevated social adjustment difficulties. Multiple linear regression found better family functioning [B = .48, t = 2.65, p = .016], and higher executive functioning [B = -.43, t = -2.39, p = .028] were related to higher scores on the PedsQL parent-proxy ratings of social adjustment [F(4,18) = 5.88, p = .003]. Male sex [B = .54, t = 3.08, p = .005], and having lived more years in Canada [B = .55, t = 2.81, p = .009], were related to higher PedsQL self-reported social adjustment [F(4,23) = 3.75, p = .017]. The model examining the BASC-3 withdrawal subscale was not statistically significant [F(4,16) = 1.63, p = .22].
Social adjustment in children diagnosed with SCD warrants future research to understand the influence of executive function, and non-disease-related factors, particularly focusing on sociocultural factors.
患有镰状细胞病 (SCD) 的儿童面临身体、心理和社会适应方面的挑战。本研究旨在调查患有 SCD 的儿童的社会适应情况及其相关因素。
数据来自一家三级儿科医院神经心理学诊所的 32 名儿童（50%为男性，平均年龄为 10.32 岁，标准差为 3.27）。使用儿童行为评估系统（BASC-3）家长代理的行为量表和儿科生活质量量表（PedsQL）通用模块的社交功能自我和家长代理子量表来测量社会适应能力。其他措施包括执行功能（即行为评定量表的第二版（BRIEF-2）家长形式）和与社会适应能力相关的非疾病因素，包括在加拿大的年限和家庭功能（即 PedsQL 家庭影响模块）。
16%的患者报告存在社会适应困难。多元线性回归发现，更好的家庭功能[B=.48，t=2.65，p=.016]和更高的执行功能[B=-.43，t=-2.39，p=.028]与 PedsQL 家长代理对社交适应的评分更高相关[F(4,18)=5.88，p=.003]。男性性别[B=.54，t=3.08，p=.005]和在加拿大生活的时间更长[B=.55，t=2.81，p=.009]与 PedsQL 自我报告的社会适应更高相关[F(4,23)=3.75，p=.017]。BASC-3 退缩分量表的模型不具有统计学意义[F(4,16)=1.63，p=.22]。
患有 SCD 的儿童的社会适应能力需要进一步研究，以了解执行功能和非疾病相关因素的影响，特别是要关注社会文化因素。
