Hofmann R, Lehmer A, Braun J, Bauer S
Urol Res. 1986;14(6):327-30. doi: 10.1007/BF00262385.
Chemilumenescence (CL) occurs due to the phagocytosis of bacteria and of tumor cells by polymorphonuclear neutrophils (PMN). Levels of CL were measured in patients with prostatic cancer and from normal subjects. Patients with advanced disease (stage C, D) showed no elevated CL levels as compared to healthy individuals or patients with minimal disease (stage A, B). Following external radiation therapy in patients with stage A-C prostatic carcinoma high levels of CL were recorded. Estrogen medication also resulted in increased CL levels, while estramustine did not affect phagocytic activity. Intradermal BCG vaccination caused increased PMN activity. Progressive prostatic cancer in hormone treated patients was associated with increased CL as compared to patients with stable or regressive disease.
化学发光（CL）是由于多形核中性粒细胞（PMN）对细菌和肿瘤细胞的吞噬作用而产生的。对前列腺癌患者和正常受试者的化学发光水平进行了测量。与健康个体或疾病轻微（A、B期）的患者相比，晚期疾病（C、D期）患者的化学发光水平没有升高。在A - C期前列腺癌患者接受外照射治疗后，记录到高水平的化学发光。雌激素药物治疗也导致化学发光水平升高，而雌莫司汀不影响吞噬活性。皮内接种卡介苗可导致PMN活性增加。与疾病稳定或消退的患者相比，接受激素治疗的进展性前列腺癌患者的化学发光增加。
