Department of General Thoracic Surgery, Social Welfare Organization Saiseikai Imperial Gift Foundation, Chibaken Saiseikai Narashino Hospital, 1-8-1 Izumi-Cho, Narashino-Shi, Chiba, 275-8580, Japan.
Department of Radiology, Teikyo University School of Medicine, Tokyo, Japan.
Radiat Oncol. 2023 Dec 18;18(1):201. doi: 10.1186/s13014-023-02387-1.
This study aimed to compare the outcomes of patients with ground-grass opacity (GGO)-dominant non-small cell lung cancer (NSCLC) who were treated with carbon ion radiotherapy (CIRT) versus segmentectomy.
A retrospective review of medical records was conducted. The study included 123 cases of clinical stage 0/IA peripheral NSCLC treated with single-fraction CIRT from 2003 to 2012, 14 of which were determined to be GGO-dominant and were assigned to CIRT group. As a control, 48 consecutive patients who underwent segmentectomy for peripheral GGO-dominant clinical stage IA NSCLC were assigned to segmentectomy group.
The patients in CIRT group, compared with segmentectomy group, were significantly older (75 ± 7.2 vs. 65 ± 8.2 years, P = 0.000660), more likely to be male (13/14 vs. 22/48, P = 0.00179), and had a lower forced vital capacity (91 ± 19% vs. 110 ± 13%, P = 0.0173). There was a significant difference in the 5-years overall survival rate (86% vs. 96%, P = 0.000860), but not in the 5-years disease-specific survival rate (93% vs. 98%, P = 0.368).
Compared with segmentectomy, CIRT may be an alternative option for patients with early GGO-dominant NSCLC who are poor candidates for, or who refuse, surgery.
本研究旨在比较行碳离子放疗（CIRT）与肺段切除术治疗磨玻璃密度（GGO）为主型非小细胞肺癌（NSCLC）患者的疗效。
对病历进行回顾性分析。研究纳入了 2003 年至 2012 年间接受单次分割 CIRT 治疗的 123 例临床 I 期周围型 NSCLC 患者，其中 14 例为 GGO 为主型，归入 CIRT 组。作为对照，48 例接受肺段切除术治疗的临床 I 期周围型 GGO 为主型 NSCLC 患者归入肺段切除术组。
与肺段切除术组相比，CIRT 组患者年龄更大（75±7.2 岁 vs. 65±8.2 岁，P=0.000660），男性比例更高（13/14 例 vs. 22/48 例，P=0.00179），用力肺活量（FVC）更低（91±19% vs. 110±13%，P=0.0173）。两组患者 5 年总生存率（86% vs. 96%，P=0.000860）差异有统计学意义，但 5 年无病生存率（93% vs. 98%，P=0.368）差异无统计学意义。
与肺段切除术相比，CIRT 可能是不能手术或拒绝手术的早期 GGO 为主型 NSCLC 患者的一种替代治疗方法。
