NAP3.0-SE Neuropsychopharmacology Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest, Hungary.
SE NAP 2 Genetic Brain Imaging Migraine Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest, Hungary.
Cephalalgia. 2023 Dec;43(12):3331024231216456. doi: 10.1177/03331024231216456.
Diffusion-tensor imaging can be applied to describe the microstructural integrity of the whole brain. As findings about microstructural alterations in migraine are inconsistent, we aimed to replicate the most frequent results and assess a relationship between migraine parameters and changes in microstructure.
Diffusion-weighted MRI data of 37 migraine patients and 40 controls were collected. Two indices of diffusion of water molecules, fractional anisotropy and mean diffusivity were used in a voxel-wise analysis. Group comparisons were carried out in SPM12 using age and sex as covariates. Statistically significant results survived family-wise error correction (p < 0.05). Migraine intensity, frequency, and duration were self-reported and correlated with mean fractional anisotropy and mean diffusivity values across clusters.
Migraine patients showed significantly lower fractional anisotropy in occipital regions, and significantly higher fractional anisotropy in thirteen clusters across the brain. Mean diffusivity of migraine patients was significantly decreased in the cerebellum and pons, but it was not increased in any area. Correlation between migraine duration and fractional anisotropy was significantly positive in the frontal cortex and significantly negative in the superior parietal lobule.
We suggest that microstructural integrity of the migraine brain is impaired in visual areas and shows duration-related alterations in regions of the default mode network.
弥散张量成像可用于描述整个大脑的微观结构完整性。由于偏头痛患者微观结构改变的研究结果不一致，我们旨在复制最常见的结果，并评估偏头痛参数与微观结构变化之间的关系。
收集了 37 名偏头痛患者和 40 名对照者的弥散加权 MRI 数据。采用体素分析方法，使用水分子扩散的两个指标，即各向异性分数和平均弥散度。使用 SPM12 进行组间比较，以年龄和性别为协变量。通过家族性错误校正（p < 0.05），对具有统计学意义的结果进行校正。偏头痛的强度、频率和持续时间由患者自我报告，并与跨聚类的平均各向异性分数和平均弥散度值相关。
偏头痛患者在枕叶区域的各向异性分数明显降低，在大脑的 13 个区域的各向异性分数明显升高。偏头痛患者的小脑和脑桥的平均弥散度明显降低，但在任何区域均未增加。偏头痛持续时间与额皮质的各向异性分数呈显著正相关，与顶叶上回的各向异性分数呈显著负相关。
我们认为，偏头痛患者大脑的微观结构完整性在视觉区域受损，在默认模式网络区域存在与持续时间相关的改变。
