Espiridion Eduardo D, Saxena Sonam
Psychiatry, West Virginia School of Osteopathic Medicine, Lewisburg, USA.
Psychiatry, Drexel University College of Medicine, Philadelphia, USA.
Cureus. 2023 Nov 17;15(11):e48978. doi: 10.7759/cureus.48978. eCollection 2023 Nov.
Priapism is a painful and emergent side effect that has been linked to some antipsychotics and other psychiatric medications, most often trazodone. This is thought to be due to some level of alpha-1 adrenergic blockade by these medications. Aripiprazole is an atypical antipsychotic with notably weak alpha-1 adrenergic antagonism. Thus, we report on a unique case of aripiprazole-induced priapism in a patient with schizophrenia and recurrent episodes of antipsychotic-induced priapism. This study offers insight into the potential mechanism of aripiprazole-induced priapism and offers alternative medications, such as olanzapine and lumateperone, to treat the patient's ongoing psychotic disorder.
阴茎异常勃起是一种痛苦且紧急的副作用，与某些抗精神病药物及其他精神科药物有关，最常见的是曲唑酮。这被认为是由于这些药物在一定程度上阻断了α-1肾上腺素能受体。阿立哌唑是一种非典型抗精神病药物，其α-1肾上腺素能拮抗作用明显较弱。因此，我们报告了一例患有精神分裂症且有抗精神病药物诱发阴茎异常勃起复发史的患者出现阿立哌唑诱发阴茎异常勃起的独特病例。本研究深入探讨了阿立哌唑诱发阴茎异常勃起的潜在机制，并提供了替代药物，如奥氮平和鲁马哌酮，以治疗该患者持续存在的精神障碍。
