Basic Medical College of Nanchang University, Department of Physiology, Nanchang, 330006, P.R. China.
Jiangxi Provincial Key Laboratory of autonomic nervous function and disease, Nanchang, 330006, P.R. China.
J Appl Biomed. 2023 Dec;21(4):193-199. doi: 10.32725/jab.2023.021. Epub 2023 Dec 4.
Naringin inhibits inflammation and oxidative stress, the P2 purinoreceptor X4 receptor (P2X4R) is associated with glial cell activation and inflammation, the purpose of this study is to investigate the effects of naringin on P2X4 receptor expression on satellite glial cells (SGCs) and its possible mechanisms. ATP promoted the SGC activation and upregulated P2X4R expression; naringin inhibited SGC activation, decreased expression of P2X4R, P38 MAPK/ERK, and NF-κB, and reduced levels of Ca2+, TNF-α, and IL-1β in SGCs in an ATP-containing environment. These findings suggest that naringin attenuates the ATP-induced SGC activation and reduces P2X4R expression via the Ca2+-P38 MAPK/ERK-NF-κB pathway.
柚皮苷抑制炎症和氧化应激，嘌呤能受体 P2X4 受体 (P2X4R) 与神经胶质细胞激活和炎症有关，本研究旨在探讨柚皮苷对卫星胶质细胞 (SGCs) 上 P2X4 受体表达的影响及其可能的机制。ATP 促进 SGC 激活并上调 P2X4R 表达；柚皮苷抑制 SGC 激活，降低 P2X4R、P38 MAPK/ERK 和 NF-κB 的表达，并降低 SGC 中 Ca2+、TNF-α 和 IL-1β 的水平在含 ATP 的环境中。这些发现表明，柚皮苷通过 Ca2+-P38 MAPK/ERK-NF-κB 通路减轻 ATP 诱导的 SGC 激活和降低 P2X4R 表达。
