[The role of lipid peroxidation in the process of thermal inactivation of tissue thromboplastin].

Thermic inactivation of tissue thromboplastin in air led to an increase in concentration of malonic dialdehyde and to decrease in activity of thromboplastin. Thromboplastin, treated with ionol, exhibited a less distinct loss of the hemocoagulation activity on heating. Inactivation of the tissue thromboplastin in air during thermic treatment involved at least three steps: thermic denaturation of apoprotein III, lipid peroxidation of the lipid component, observed in the experiment, oxidation of apoprotein III and destruction of its lipid moiety.