[Antioxidant activity of the drug distinol in vitro].

Distinol, ionol and dimethylsulphoxide were investigated in model reaction of thermal oxidation of methyl oleate for their antioxidant activity and for their influence on the rate of malonic dialdehyde formation in the liver tissue of chicken with E-hypovitaminosis in vitro. It has been found that the level of antioxidant activity in the homogeneous system of methyl oleate oxidation permits arranging the preparations studied in a series: ionol > distinol > dimethylsulphoxide. Distinol inhibits peroxidation of lipids in the liver homogenates of chicken most efficiently. Its inhibitory effect is 4.6 times higher than that of dimethylsulphoxide and 1.3 times higher than that of ionol. No correlation was found between antioxidant activity of distinol in the homogeneous model system and its influence on peroxidation of lipids in biomembranes.