蜘蛛恐惧症的抑制控制及其改变 - 反向眼跳训练试验的研究方案。
Inhibitory control and its modification in spider phobia - Study protocol for an antisaccade training trial.
机构信息
Department of Psychology, Clinical Psychology and Psychotherapy, University of Siegen, Siegen, Germany.
Institute for Translational Psychiatry, University of Münster, Münster, Germany.
出版信息
PLoS One. 2023 Dec 19;18(12):e0292471. doi: 10.1371/journal.pone.0292471. eCollection 2023.
OBJECTIVES
Inhibitory control deficits are considered a key pathogenic factor in anxiety disorders. To assess inhibitory control, the antisaccade task is a well-established measure that assesses antisaccade performance via latencies and error rates. The present study follows three aims: (1) to investigate inhibitory control via antisaccade latencies and errors in an antisaccade task, and their associations with multiple measures of fear in patients with spider phobia (SP) versus healthy controls (HC), (2) to investigate the modifiability of antisaccade performance via a fear-specific antisaccade training in patients with SP and HC, and (3) to explore associations between putative training-induced changes in antisaccade performance in SPs and changes in diverse measures of fear.
METHODS
Towards aim 1, we assess antisaccade latencies (primary outcome) and error rates (secondary outcome) in an emotional antisaccade task. Further, the baseline assessment includes assessments of psychophysiological, behavioral, and psychometric indices of fear in patients with SP and HCs. To address aim 2, we compare effects of a fear-specific antisaccade training with effects of a prosaccade training as a control condition. The primary and secondary outcomes are reassessed at a post-1-assessment in both SPs and HCs. Aim 3 employs a cross-over design and is piloted in patients with SP, only. Towards this aim, primary and secondary outcomes, as well as psychophysiological, behavioral, and psychometric measures of fear are reassessed at a post-2-assessment after the second training block.
CONCLUSION
This study aims to better understand inhibitory control processes and their modifiability in spider phobia. If successful, antisaccade training may assist in the treatment of specific phobia by directly targeting the putative underlying inhibitory control deficits. This study has been preregistered with ISRCTN (ID: ISRCTN12918583) on 28th February 2022.
目的
抑制控制缺陷被认为是焦虑障碍的一个关键致病因素。为了评估抑制控制，反扫视任务是一种经过充分验证的测量方法，通过潜伏期和错误率来评估反扫视表现。本研究旨在实现三个目标：（1）通过蜘蛛恐惧症（SP）患者和健康对照者（HC）的反扫视任务中的反扫视潜伏期和错误率来研究抑制控制，以及它们与恐惧的多种测量指标之间的关系；（2）通过对 SP 和 HC 进行恐惧特异性反扫视训练来研究反扫视表现的可变性；（3）探讨 SP 中反扫视表现的潜在训练诱导变化与恐惧的各种测量指标之间的关系。
方法
为了实现目标 1，我们评估了情绪反扫视任务中的反扫视潜伏期（主要结果）和错误率（次要结果）。此外，基线评估包括评估 SP 和 HC 中恐惧的生理心理、行为和心理计量学指标。为了实现目标 2，我们比较了恐惧特异性反扫视训练与正扫视训练（作为对照条件）的效果。在 SP 和 HC 中进行了一次 1 后评估后，重新评估了主要和次要结果。目标 3 采用交叉设计，仅在 SP 患者中进行试点。为此，在第二个训练块后进行第二次评估时，重新评估了主要和次要结果以及恐惧的生理心理、行为和心理计量学指标。
结论
本研究旨在更好地了解蜘蛛恐惧症中的抑制控制过程及其可变性。如果成功，反扫视训练可以通过直接针对潜在的抑制控制缺陷来辅助特定恐惧症的治疗。该研究已在 2022 年 2 月 28 日在 ISRCTN 上进行了预注册（ID：ISRCTN8583）。
Zotero 插件