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全身性炎症下的垂体-免疫双向交流。

Pituitary-immune bidirectional crosstalk under systemic inflammation.

机构信息

Department of Neuroscience, Department of Genetics, Hope Center for Neurological Disorders, Center for Brain Immunology and Glia, Washington University in St. Louis School of Medicine, St. Louis, Missouri, United States of America.

出版信息

PLoS Biol. 2023 Dec 19;21(12):e3002440. doi: 10.1371/journal.pbio.3002440. eCollection 2023 Dec.

DOI:10.1371/journal.pbio.3002440
PMID:38113236
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10729977/
Abstract

The pituitary gland responds to and modulates immune stress through the hypothalamus-pituitary-adrenal axis. A new study in PLOS Biology reveals unconventional bidirectional communication between hormone-producing cells and the immune system upon systemic inflammation.

摘要

垂体通过下丘脑-垂体-肾上腺轴对免疫应激做出反应并进行调节。PLOS Biology 的一项新研究揭示了全身炎症时激素产生细胞与免疫系统之间的非传统双向通讯。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e0a/10729977/92abf3ec1a5b/pbio.3002440.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e0a/10729977/92abf3ec1a5b/pbio.3002440.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e0a/10729977/92abf3ec1a5b/pbio.3002440.g001.jpg

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1
Pituitary-immune bidirectional crosstalk under systemic inflammation.全身性炎症下的垂体-免疫双向交流。
PLoS Biol. 2023 Dec 19;21(12):e3002440. doi: 10.1371/journal.pbio.3002440. eCollection 2023 Dec.
2
Single-cell transcriptomic analysis reveals rich pituitary-Immune interactions under systemic inflammation.单细胞转录组分析揭示了系统性炎症下丰富的垂体-免疫相互作用。
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[Immuno-endocrine interactions at the hypothalamo-hypophyseal level].[下丘脑 - 垂体水平的免疫 - 内分泌相互作用]
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本文引用的文献

1
Single-cell transcriptomic analysis reveals rich pituitary-Immune interactions under systemic inflammation.单细胞转录组分析揭示了系统性炎症下丰富的垂体-免疫相互作用。
PLoS Biol. 2023 Dec 18;21(12):e3002403. doi: 10.1371/journal.pbio.3002403. eCollection 2023 Dec.
2
The neuronal pentraxin Nptx2 regulates complement activity and restrains microglia-mediated synapse loss in neurodegeneration.神经元五联素 Nptx2 调节补体活性并抑制神经退行性变中的小胶质细胞介导的突触丢失。
Sci Transl Med. 2023 Mar 29;15(689):eadf0141. doi: 10.1126/scitranslmed.adf0141.
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The HPA - Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain.
下丘脑-垂体-肾上腺轴与糖皮质激素在大脑中的免疫调节作用
Front Immunol. 2014 Mar 31;5:136. doi: 10.3389/fimmu.2014.00136. eCollection 2014.
4
Pentraxins: structure, function, and role in inflammation.五聚体蛋白：结构、功能及在炎症中的作用
ISRN Inflamm. 2013 Sep 14;2013:379040. doi: 10.1155/2013/379040.
5
Narp regulates homeostatic scaling of excitatory synapses on parvalbumin-expressing interneurons.Narp 调节表达 Parvalbumin 的中间神经元上兴奋性突触的稳态缩放。
Nat Neurosci. 2010 Sep;13(9):1090-7. doi: 10.1038/nn.2621. Epub 2010 Aug 22.
6
Narp and NP1 form heterocomplexes that function in developmental and activity-dependent synaptic plasticity.Narp和NP1形成异源复合物，在发育和活动依赖的突触可塑性中发挥作用。
Neuron. 2003 Jul 31;39(3):513-28. doi: 10.1016/s0896-6273(03)00463-x.
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Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin.迷走神经刺激可减轻对内毒素的全身炎症反应。
Nature. 2000 May 25;405(6785):458-62. doi: 10.1038/35013070.
8
The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation.下丘脑-垂体-肾上腺轴与免疫介导的炎症。
N Engl J Med. 1995 May 18;332(20):1351-62. doi: 10.1056/NEJM199505183322008.
9
Subdiaphragmatic vagotomy suppresses endotoxin-induced activation of hypothalamic corticotropin-releasing hormone neurons and ACTH secretion.膈下迷走神经切断术可抑制内毒素诱导的下丘脑促肾上腺皮质激素释放激素神经元的激活及促肾上腺皮质激素的分泌。
Endocrinology. 1995 Oct;136(10):4717-20. doi: 10.1210/endo.136.10.7664696.