Knoflach P
Wien Klin Wochenschr. 1986 Nov 21;98(22):754-8.
The aetiology and pathogenesis of Crohn's disease and ulcerative colitis have not yet been clarified. None of the many investigations on the involvement of genetic, microbial, psychological, immunological and environmental factors have been able to identify a single aetiological agent. Nevertheless, all of these factors could play a role in a multifactorial model of the aetiology and pathogenesis of inflammatory bowel disease.
克罗恩病和溃疡性结肠炎的病因及发病机制尚未阐明。关于遗传、微生物、心理、免疫和环境因素参与其中的众多研究,均未能确定单一的病因。然而,在炎症性肠病病因和发病机制的多因素模型中,所有这些因素都可能发挥作用。