血小板计数和血小板因子升高与马里儿童体内恶性疟原虫密度降低有关。
Higher platelet counts and platelet factors are associated with a reduction in Plasmodium falciparum parasite density in young Malian children.
机构信息
Malaria Research & Training Center, Faculty of Medicine, Pharmacy and Dentistry, University of Sciences Techniques and Technologies of Bamako, Bamako, Mali.
Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA.
出版信息
Int J Infect Dis. 2024 Feb;139:171-175. doi: 10.1016/j.ijid.2023.12.005. Epub 2023 Dec 17.
OBJECTIVES
The association between thrombocytopenia and parasite density or disease severity is described in numerous studies. In recent years, several studies described the protective role of platelets in directly killing Plasmodium parasites, mediated by platelet factor 4 (PF4) binding to Duffy antigen. This study aimed to evaluate the protective role of platelets in young children who are Duffy antigen-negative, such as those in sub-Saharan Africa.
METHODS
A zero-inflated negative binomial model was used to relate platelet count and parasite density data collected in a longitudinal birth cohort. Platelet factors were measured by enzyme-linked immunosorbent assay in samples collected from malaria-infected children who participated in a cross-sectional study.
RESULTS
We described that an increase of 10,000 platelets/μl was associated with a 2.76% reduction in parasite count. Increasing levels of PF4 and CXCL7 levels were also significantly associated with a reduction in parasite count.
CONCLUSIONS
Platelets play a protective role in reducing parasite burden in Duffy-negative children, possibly mediated through activation of the innate immune system.
目的
许多研究描述了血小板减少症与寄生虫密度或疾病严重程度之间的关联。近年来，有几项研究描述了血小板通过血小板因子 4（PF4）与 Duffy 抗原结合来直接杀死疟原虫寄生虫的保护作用。本研究旨在评估在达菲抗原阴性的幼儿（如撒哈拉以南非洲地区的儿童）中血小板的保护作用。
方法
使用零膨胀负二项式模型将纵向出生队列中收集的血小板计数和寄生虫密度数据相关联。在参加横断面研究的疟疾感染儿童的样本中，通过酶联免疫吸附试验测量血小板因子。
结果
我们描述了血小板计数每增加 10,000/μl，寄生虫计数就会减少 2.76%。PF4 和 CXCL7 水平的升高也与寄生虫计数的减少显著相关。
结论
血小板在减少达菲阴性儿童的寄生虫负担方面发挥保护作用，可能通过激活先天免疫系统来介导。
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