儿童血小板增多症：来自印度东部一个单一中心的临床血液学特征

Thrombocytosis in children: Clinico-hematological profile from a single centre in Eastern India.

作者信息

Sarangi Rachita, Pradhan Sarita, Dhanawat Avantika, Patanayak Rashmi, Benia Gautam

机构信息

Department of Paediatrics, IMS and Sum Hospital, Bhubaneswar, Odisha, India.

Department of Pathology, IMS and Sum Hospital, Bhubaneswar, Odisha, India.

出版信息

J Lab Physicians. 2018 Jan-Mar;10(1):34-37. doi: 10.4103/JLP.JLP_90_17.

DOI:10.4103/JLP.JLP_90_17

PMID:29403202

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5784290/

Abstract

BACKGROUND AND OBJECTIVE

Thrombocytosis is not an uncommon finding in hemograms of children with an incidence of 6%-15% among hospitalized children. This study aims to determine the etiology of thrombocytosis and analyze various platelet parameters in children attending our hospital.

MATERIALS AND METHODS

A prospective observational study was carried out in a tertiary care center in Odisha, in eastern part of India, for 6 months from July 2016 to December 2016. All children of age group 1-14 years of age attending pediatrics and other pediatric super specialty outdoors and/or admitted to indoors and whose complete blood counts (CBC) were done were included in the study. The CBC parameters such as hemoglobin, red blood cell indices, and platelet indices (platelet distribution width [PDW], mean platelet volume [MPV], platelet large cell ratio [P-LCR]) were noted.

RESULTS

Out of 2500 hemograms done in pediatrics age group, 272 (10.8%) patients showed thrombocytosis. About 99.6% of cases were of secondary thrombocytosis. Only one case of primary thrombocytosis was encountered. The most common cause of secondary thrombocytosis was infection (39.5%) alone followed by iron deficiency anemia (14.1%). With increasing platelet counts, a decrease in MPV, P-LCR, and PDW was noted which was statistically significant ( < 0.05).

CONCLUSION

Thrombocytosis is not rare (10.8%) in children. Secondary thrombocytosis is common and predominatly attributed to infection.

摘要

背景与目的

血小板增多症在儿童血常规检查中并不罕见，住院儿童中的发病率为6%-15%。本研究旨在确定儿童血小板增多症的病因，并分析我院就诊儿童的各项血小板参数。

材料与方法

2016年7月至2016年12月，在印度东部奥里萨邦的一家三级医疗中心进行了一项为期6个月的前瞻性观察研究。纳入所有年龄在1-14岁、在儿科及其他儿科专科门诊就诊和/或住院且进行了全血细胞计数（CBC）的儿童。记录CBC参数，如血红蛋白、红细胞指数和血小板指数（血小板分布宽度[PDW]、平均血小板体积[MPV]、血小板大细胞比率[P-LCR]）。

结果

在儿科年龄组进行的2500份血常规检查中，272例（10.8%）患者出现血小板增多症。约99.6%的病例为继发性血小板增多症。仅发现1例原发性血小板增多症病例。继发性血小板增多症最常见的原因是单纯感染（39.5%），其次是缺铁性贫血（14.1%）。随着血小板计数增加，MPV、P-LCR和PDW降低，差异有统计学意义（<0.05）。