Burt A, Goudie R B
Histopathology. 1979 Jul;3(4):279-86. doi: 10.1111/j.1365-2559.1979.tb03009.x.
Thyroglobulin was found by the immunoperoxidase technique in routine histological sections of biopsies from all of 30 proven cases of well differentiated papillary or follicular thyroid carcinoma examined, in one of 20 anaplastic thyroid tumours and in none of 49 other tumours examined. Immunohistological demonstration of thyroglobulin in thyroidal or extrathyroidal tumours is of diagnostic value in confirming that the thyroid is the tissue of origin. Well differentiated tumours lacking thyroglobulin probably do not arise from thyroid epithelium.
在通过免疫过氧化物酶技术检查的30例已确诊的高分化乳头状或滤泡状甲状腺癌活检的常规组织切片中均发现了甲状腺球蛋白，在20例间变性甲状腺肿瘤中有1例发现了甲状腺球蛋白，而在检查的49例其他肿瘤中均未发现。甲状腺或甲状腺外肿瘤中甲状腺球蛋白的免疫组织学证明对于确认甲状腺是起源组织具有诊断价值。缺乏甲状腺球蛋白的高分化肿瘤可能并非起源于甲状腺上皮。
