School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Cerebrovascular Disease Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.
Learn Mem. 2023 Dec 19;30(12):325-337. doi: 10.1101/lm.053893.123. Print 2023 Dec.
Memory retrieval is strikingly susceptible to external states (environment) and internal states (mood states and alcohol), yet we know little about the underlying mechanisms. We examined how internally generated states influence successful memory retrieval using the functional magnetic resonance imaging (fMRI) of laboratory mice during memory retrieval. Mice exhibited a strong tendency to perform memory retrieval correctly only in the reinstated mammillary body-inhibited state, in which mice were trained to discriminate auditory stimuli in go/no-go tasks. fMRI revealed that distinct auditory cues engaged differential brain regions, which were primed by internal state. Specifically, a cue associated with a reward activated the lateral amygdala, while a cue signaling no reward predominantly activated the postsubiculum. Modifying these internal states significantly altered the neural activity balance between these regions. Optogenetic inhibition of those regions in the precue period blocked the retrieval of type-specific memories. Our findings suggest that memory retrieval is under the control of two interrelated neural circuits underlying the neural basis of state-dependent memory retrieval.
记忆检索对外界状态（环境）和内部状态（情绪状态和酒精）非常敏感，但我们对其潜在机制知之甚少。我们使用实验室小鼠的功能磁共振成像（fMRI）在记忆检索期间检查了内部生成的状态如何影响成功的记忆检索。只有在重新建立的乳头体抑制状态下，小鼠才表现出强烈的正确进行记忆检索的趋势，在这种状态下，小鼠被训练在 Go/No-Go 任务中区分听觉刺激。fMRI 显示，不同的听觉线索激活了不同的大脑区域，这些区域是由内部状态引发的。具体来说，与奖励相关的线索会激活外侧杏仁核，而表示无奖励的线索则主要激活后下托。改变这些内部状态会显著改变这些区域之间的神经活动平衡。在提示前期间对这些区域进行光遗传抑制会阻止特定类型记忆的检索。我们的研究结果表明，记忆检索受到两个相互关联的神经回路的控制，这是状态依赖记忆检索的神经基础。
