Department of Biomedical Engineering, School of Bioinformatics, Chongqing University of Posts and Telecommunications, Chongqing, China.
Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.
Sci Rep. 2020 Feb 11;10(1):2370. doi: 10.1038/s41598-020-59195-w.
Recent studies have revealed structural and functional abnormalities in amygdala due to Internet addiction (IA) associated with emotional disturbance. However, the role of amygdala connectivity that is responsible for emotion-cognition interactions is largely unknown in IA. This study aims to explore the amygdala connectivity abnormalities in IA. The functional and structural connectivity of bilateral amygdala were examined using seed-based connectivity analysis, and the structural integrity on white mater tracts passing through amygdala was also examined. Additionally, a correlation analysis was performed to investigate the relationship between brain connectivity and duration of IA. We found that IA subjects had decreased negative functional connectivity (FC) between amygdala and dorsolateral prefrontal cortex (DLPFC), and had increased negative FC between amygdala and precuneus and superior occipital gyrus (SOG). While IA subjects had decreased positive FC between amygdala and anterior cingulate cortex (ACC), and had increased positive FC between amygdala and thalamus. The FC between left amygdala and right DLPFC had significant correlation with duration of IA. The structural connectivity and integrity between amygdala and ACC were also decreased in IA subjects. These findings indicate that the amygdala connectivity is altered in IA subjects. The altered FC of amygdala-DLPFC is associated with duration of IA.
最近的研究表明，由于与情绪障碍相关的网络成瘾（IA），杏仁核存在结构和功能异常。然而，负责情绪-认知相互作用的杏仁核连接的作用在 IA 中很大程度上是未知的。本研究旨在探讨 IA 中杏仁核连接的异常。使用基于种子的连接分析检查双侧杏仁核的功能和结构连接，并检查穿过杏仁核的白质束的结构完整性。此外，还进行了相关性分析，以研究脑连接与 IA 持续时间之间的关系。我们发现，IA 患者的杏仁核与背外侧前额叶皮层（DLPFC）之间的负性功能连接（FC）降低，而杏仁核与后扣带回和上顶叶（SOG）之间的负 FC 增加。IA 患者的杏仁核与前扣带皮层（ACC）之间的正 FC 降低，而杏仁核与丘脑之间的正 FC 增加。左杏仁核与右 DLPFC 之间的 FC 与 IA 的持续时间呈显著相关性。IA 患者的杏仁核与 ACC 之间的结构连接和完整性也降低。这些发现表明，IA 患者的杏仁核连接发生了改变。杏仁核-背外侧前额叶皮层的改变 FC 与 IA 的持续时间有关。
