• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

DPY30通过上调ZEB1转录表达促进结直肠癌转移。

DPY30 promotes colorectal carcinoma metastasis by upregulating ZEB1 transcriptional expression.

作者信息

Luo Chun-Ying, Su Wei-Chao, Jiang Hai-Feng, Luo Ling-Tao, Shen Dong-Yan, Su Guo-Qiang

机构信息

Medical College, Guangxi University, Nanning, 530004, Guangxi Province, People's Republic of China.

Department of Pathology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, 533000, Guangxi Province, People's Republic of China.

出版信息

Cancer Cell Int. 2023 Dec 19;23(1):333. doi: 10.1186/s12935-023-03126-y.

DOI:10.1186/s12935-023-03126-y
PMID:38115111
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10731791/
Abstract

DPY30 belongs to the core subunit of components of the histone lysine methyltransferase complex, which is implicated in tumorigenesis, cell senescence, and other biological events. However, its contribution to colorectal carcinoma (CRC) progression and metastasis has yet to be elucidated. Therefore, this study aimed to investigate the biological function of DPY30 in CRC metastasis both in vitro and in vivo. Herein, our results revealed that DPY30 overexpression is significantly positively correlated with positive lymph nodes, epithelial-mesenchymal transition (EMT), and CRC metastasis. Moreover, DPY30 knockdown in HT29 and SW480 cells markedly decreased EMT progression, as well as the migratory and invasive abilities of CRC cells in vitro and lung tumor metastasis in vivo. Mechanistically, DPY30 increased histone H3K4me3 level and promoted EMT and CRC metastasis by upregulating the transcriptional expression of ZEB1. Taken together, our findings indicate that DPY30 may serve as a therapeutic target and prognostic marker for CRC.

摘要

DPY30属于组蛋白赖氨酸甲基转移酶复合物组成部分的核心亚基，该复合物与肿瘤发生、细胞衰老及其他生物学事件有关。然而，其对结直肠癌（CRC）进展和转移的作用尚未阐明。因此，本研究旨在探讨DPY30在CRC转移中的体内外生物学功能。在此，我们的结果显示DPY30过表达与阳性淋巴结、上皮-间质转化（EMT）及CRC转移显著正相关。此外，HT29和SW480细胞中DPY30敲低显著降低了EMT进程以及CRC细胞的体外迁移和侵袭能力及体内肺肿瘤转移。机制上，DPY30通过上调ZEB1的转录表达增加组蛋白H3K4me3水平并促进EMT和CRC转移。综上所述，我们的研究结果表明DPY30可能作为CRC的治疗靶点和预后标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1257/10731791/24b2f6af32d6/12935_2023_3126_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1257/10731791/3e1b5e3e7426/12935_2023_3126_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1257/10731791/e7101ce83a70/12935_2023_3126_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1257/10731791/bacab4d9bcfe/12935_2023_3126_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1257/10731791/88de12599144/12935_2023_3126_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1257/10731791/85c815d30a64/12935_2023_3126_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1257/10731791/24b2f6af32d6/12935_2023_3126_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1257/10731791/3e1b5e3e7426/12935_2023_3126_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1257/10731791/e7101ce83a70/12935_2023_3126_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1257/10731791/bacab4d9bcfe/12935_2023_3126_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1257/10731791/88de12599144/12935_2023_3126_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1257/10731791/85c815d30a64/12935_2023_3126_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1257/10731791/24b2f6af32d6/12935_2023_3126_Fig6_HTML.jpg

相似文献

1
DPY30 promotes colorectal carcinoma metastasis by upregulating ZEB1 transcriptional expression.DPY30通过上调ZEB1转录表达促进结直肠癌转移。
Cancer Cell Int. 2023 Dec 19;23(1):333. doi: 10.1186/s12935-023-03126-y.
2
DPY30 knockdown suppresses colorectal carcinoma progression via inducing Raf1/MST2-mediated apoptosis.DPY30基因敲低通过诱导Raf1/MST2介导的凋亡抑制结直肠癌进展。
Heliyon. 2024 Jan 20;10(3):e24807. doi: 10.1016/j.heliyon.2024.e24807. eCollection 2024 Feb 15.
3
DPY30 Promotes Proliferation and Cell Cycle Progression of Colorectal Cancer Cells via Mediating H3K4 Trimethylation.DPY30 通过介导 H3K4 三甲基化促进结直肠癌细胞的增殖和细胞周期进程。
Int J Med Sci. 2023 May 11;20(7):901-917. doi: 10.7150/ijms.80073. eCollection 2023.
4
GRHL2 inhibits colorectal cancer progression and metastasis via oppressing epithelial-mesenchymal transition.GRHL2 通过抑制上皮-间充质转化抑制结直肠癌细胞的进展和转移。
Cancer Biol Ther. 2019;20(9):1195-1205. doi: 10.1080/15384047.2019.1599664. Epub 2019 May 7.
5
Roles of STAT3 and ZEB1 proteins in E-cadherin down-regulation and human colorectal cancer epithelial-mesenchymal transition.STAT3 和 ZEB1 蛋白在 E-钙黏蛋白下调和人结直肠癌细胞上皮-间充质转化中的作用。
J Biol Chem. 2012 Feb 17;287(8):5819-32. doi: 10.1074/jbc.M111.295964. Epub 2011 Dec 28.
6
RHBDD1 promotes colorectal cancer metastasis through the Wnt signaling pathway and its downstream target ZEB1.RHBDD1 通过 Wnt 信号通路及其下游靶标 ZEB1 促进结直肠癌转移。
J Exp Clin Cancer Res. 2018 Feb 9;37(1):22. doi: 10.1186/s13046-018-0687-5.
7
The transcription factor ZNF248 promotes colorectal cancer metastasis by binding to ZEB1.转录因子ZNF248通过与ZEB1结合促进结直肠癌转移。
J Cancer. 2024 Aug 19;15(16):5440-5450. doi: 10.7150/jca.92886. eCollection 2024.
8
HIF-1α Promotes Epithelial-Mesenchymal Transition and Metastasis through Direct Regulation of ZEB1 in Colorectal Cancer.缺氧诱导因子-1α通过直接调控ZEB1促进结直肠癌的上皮-间质转化和转移。
PLoS One. 2015 Jun 9;10(6):e0129603. doi: 10.1371/journal.pone.0129603. eCollection 2015.
9
Forkhead box K2 promotes human colorectal cancer metastasis by upregulating ZEB1 and EGFR.叉头框蛋白K2通过上调锌指E盒结合蛋白1（ZEB1）和表皮生长因子受体（EGFR）促进人类结直肠癌转移。
Theranostics. 2019 May 31;9(13):3879-3902. doi: 10.7150/thno.31716. eCollection 2019.
10
MicroRNA-302c represses epithelial-mesenchymal transition and metastasis by targeting transcription factor AP-4 in colorectal cancer.微小 RNA-302c 通过靶向结直肠癌细胞中的转录因子 AP-4 抑制上皮-间充质转化和转移。
Biomed Pharmacother. 2018 Sep;105:670-676. doi: 10.1016/j.biopha.2018.06.025. Epub 2018 Jun 12.

本文引用的文献

1
DPY30 Promotes Proliferation and Cell Cycle Progression of Colorectal Cancer Cells via Mediating H3K4 Trimethylation.DPY30 通过介导 H3K4 三甲基化促进结直肠癌细胞的增殖和细胞周期进程。
Int J Med Sci. 2023 May 11;20(7):901-917. doi: 10.7150/ijms.80073. eCollection 2023.
2
Glioblastoma stem cells reprogram chromatin in vivo to generate selective therapeutic dependencies on DPY30 and phosphodiesterases.胶质母细胞瘤干细胞在体内重新编程染色质，从而对 DPY30 和磷酸二酯酶产生选择性的治疗依赖性。
Sci Transl Med. 2022 Jan 5;14(626):eabf3917. doi: 10.1126/scitranslmed.abf3917.
3
ABHD5 inhibits YAP-induced c-Met overexpression and colon cancer cell stemness via suppressing YAP methylation.
ABHD5 通过抑制 YAP 甲基化抑制 YAP 诱导的 c-Met 过表达和结肠癌细胞干性。
Nat Commun. 2021 Nov 18;12(1):6711. doi: 10.1038/s41467-021-26967-5.
4
RAMS11 promotes CRC through mTOR-dependent inhibition of autophagy, suppression of apoptosis, and promotion of epithelial-mesenchymal transition.RAMS11通过mTOR依赖的自噬抑制、凋亡抑制和上皮-间质转化促进作用来促进结直肠癌。
Cancer Cell Int. 2021 Jun 26;21(1):321. doi: 10.1186/s12935-021-02023-6.
5
Exosome-mediated delivery of functionally active miRNA-375-3p mimic regulate epithelial mesenchymal transition (EMT) of colon cancer cells.外泌体介导的功能性 miRNA-375-3p 模拟物的递送调节结肠癌细胞的上皮间质转化（EMT）。
Life Sci. 2021 Mar 15;269:119035. doi: 10.1016/j.lfs.2021.119035. Epub 2021 Jan 13.
6
Sodium Butyrate Selectively Kills Cancer Cells and Inhibits Migration in Colorectal Cancer by Targeting Thioredoxin-1.丁酸钠通过靶向硫氧还蛋白-1选择性杀死结肠癌细胞并抑制其迁移。
Onco Targets Ther. 2020 May 27;13:4691-4704. doi: 10.2147/OTT.S235575. eCollection 2020.
7
The complex activities of the SET1/MLL complex core subunits in development and disease.SET1/MLL 复合物核心亚基在发育和疾病中的复杂活动。
Biochim Biophys Acta Gene Regul Mech. 2020 Jul;1863(7):194560. doi: 10.1016/j.bbagrm.2020.194560. Epub 2020 Apr 15.
8
JNK Pathway Mediates Low Oxygen Level Induced Epithelial-Mesenchymal Transition and Stemness Maintenance in Colorectal Cancer Cells.JNK信号通路介导低氧水平诱导的结肠癌细胞上皮-间质转化和干性维持
Cancers (Basel). 2020 Jan 16;12(1):224. doi: 10.3390/cancers12010224.
9
Upregulation of DPY30 promotes cell proliferation and predicts a poor prognosis in cholangiocarcinoma.DPY30 的上调促进了胆管癌的细胞增殖，并预示着预后不良。
Biomed Pharmacother. 2020 Mar;123:109766. doi: 10.1016/j.biopha.2019.109766. Epub 2019 Dec 14.
10
DPY30 regulates cervical squamous cell carcinoma by mediating epithelial-mesenchymal transition (EMT).DPY30 通过介导上皮-间质转化（EMT）来调控宫颈鳞状细胞癌。
Onco Targets Ther. 2019 Sep 2;12:7139-7147. doi: 10.2147/OTT.S209315. eCollection 2019.