Smell & Taste Clinic, Department of Otorhinolaryngology, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany.
Faculty of Health Sciences, Istanbul Gelisim University, Istanbul, Turkey.
Behav Brain Funct. 2023 Dec 19;19(1):24. doi: 10.1186/s12993-023-00225-8.
Parosmia is a qualitative olfactory dysfunction presenting as "distorted odor perception" in presence of an odor source. Aim of this study was to use resting state functional connectivity to gain more information on the alteration of olfactory processing at the level of the central nervous system level.
A cross sectional study was performed in 145 patients with parosmia (age range 20-76 years; 90 women). Presence and degree of parosmia was diagnosed on the basis of standardized questionnaires. Participants also received olfactory testing using the "Sniffin' Sticks". Then they underwent resting state scans using a 3 T magnetic resonance imaging scanner while fixating on a cross.
Whole brain analyses revealed reduced functional connectivity in salience as well as executive control networks. Region of interest-based analyses also supported reduced functional connectivity measures between primary and secondary olfactory eloquent areas (temporal pole, supramarginal gyrus and right orbitofrontal cortex; dorso-lateral pre-frontal cortex and the right piriform cortex).
Participants with parosmia exhibited a reduced information flow between memory, decision making centers, and primary and secondary olfactory areas.
幻嗅是一种定性的嗅觉功能障碍，表现为在有气味源的情况下“扭曲的气味感知”。本研究的目的是使用静息态功能连接来获得更多关于中枢神经系统水平嗅觉处理改变的信息。
对 145 名幻嗅患者（年龄 20-76 岁；90 名女性）进行了横断面研究。基于标准化问卷诊断幻嗅的存在和程度。参与者还使用“Sniffin' Sticks”进行嗅觉测试。然后，他们在固定于十字的情况下使用 3T 磁共振成像扫描仪进行静息状态扫描。
全脑分析显示，显着性和执行控制网络的功能连接减少。基于感兴趣区域的分析也支持初级和次级嗅觉区域（颞极、缘上回和右侧眶额皮层；背外侧前额叶皮层和右侧梨状皮层）之间功能连接测量值的减少。
幻嗅患者表现出记忆、决策中心以及初级和次级嗅觉区域之间信息流减少。
