Department of General Surgery, the First People's Hospital of Shuangliu District, Chengdu, Sichuan Province, China.
Medicine (Baltimore). 2023 Dec 15;102(50):e36608. doi: 10.1097/MD.0000000000036608.
This study aimed to explore the value of tumor-infiltrating Forkhead box P3(FoxP3+) regulatory T cells (Tregs) in evaluating the prognosis of biliary tract cancer.
Four electronic databases were searched using 2 computers: PubMed, Embase, Web of Science, and Cochrane Library. The vocabulary and syntax were adapted according to the database. Two researchers independently selected the studies, collected information, and assessed the risk of bias. The Meta-analysis was performed using STATA 17.0, and HR and its corresponding 95% CI were used to evaluate the correlation between FoxP3+ Tregs and the overall survival of patients with biliary tract cancer. In addition, the quality of the included studies was evaluated.
Ten articles were included in this study. The results of the meta-analysis showed that patients with high FoxP3+ Tregs infiltration had worse overall survival (OS) (HR = 1.34,95% CI 1.16 to 1.71; P < .001). Subgroup analysis of gallbladder carcinoma and cholangiocarcinoma showed that the high infiltration of FoxP3+ Tregs was significantly correlated with the OS of the former (HR = 1.55,95% CI 1.11 to 2.00; P < .001), but not with the OS of the latter (HR = 1.00,95% CI 0.62 to 1.38; P > .05).
Our meta-analysis reveals that high infiltration of FoxP3 + Tregs is significantly associated with reduced overall survival in gallbladder carcinoma, endorsing their use as a prognostic biomarker for this subtype. In contrast, no significant prognostic correlation was identified for FoxP3+ Tregs in cholangiocarcinoma, indicating the need for subtype-specific evaluation of their prognostic relevance in biliary tract cancers.
本研究旨在探讨肿瘤浸润性叉头框 P3（FoxP3+）调节性 T 细胞（Tregs）在评估胆道癌预后中的价值。
使用 2 台计算机，通过 4 个电子数据库进行搜索：PubMed、Embase、Web of Science 和 Cochrane Library。根据数据库调整词汇和语法。两名研究人员独立选择研究、收集信息并评估偏倚风险。使用 STATA 17.0 进行 Meta 分析，使用 HR 及其相应的 95%CI 评估 FoxP3+Tregs 与胆道癌患者总生存期的相关性。此外，评估了纳入研究的质量。
本研究纳入了 10 篇文章。Meta 分析结果表明，FoxP3+Tregs 浸润程度高的患者总生存期（OS）更差（HR=1.34，95%CI 1.16-1.71；P<.001）。胆囊癌和胆管癌的亚组分析显示，FoxP3+Tregs 高浸润与前者的 OS 显著相关（HR=1.55，95%CI 1.11-2.00；P<.001），但与后者的 OS 无关（HR=1.00，95%CI 0.62-1.38；P>.05）。
我们的 Meta 分析表明，FoxP3+Tregs 浸润程度高与胆囊癌总生存期降低显著相关，支持将其作为该亚型的预后生物标志物。相比之下，FoxP3+Tregs 在胆管癌中与预后无显著相关性，表明需要对胆道癌中 FoxP3+Tregs 的预后相关性进行亚型特异性评估。
