Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Cell Genom. 2023 Dec 13;3(12):100456. doi: 10.1016/j.xgen.2023.100456.
The complement system is crucial for innate immunity and has been linked to autoimmune and psychiatric disorders. Borbye-Lorenzen et al. perform GWASs and PheWASs of neonatal C3/C4 protein concentrations, finding multiple genome-wide significant loci, and identify sex-specific associations between C3 protein concentration and C4 copy number with risk for schizophrenia.
补体系统对于先天免疫至关重要，并且与自身免疫和精神疾病有关。Borbye-Lorenzen 等人对新生儿 C3/C4 蛋白浓度进行了 GWAS 和 PheWAS 分析，发现了多个全基因组显著位点，并确定了 C3 蛋白浓度与 C4 拷贝数之间与精神分裂症风险的性别特异性关联。
