Schuit K E
Infect Immun. 1979 Jun;24(3):932-8. doi: 10.1128/iai.24.3.932-938.1979.
The kinetics of phagocytosis and killing of four fungal forms with varying virulence by two types of phagocytic cells was examined. Human monocytes ingested Saccharomyces cerevisiae, Candida tropicalis, and the blastospores of Candida albicans more rapidly than did human neutrophils. There was no difference in the rate of phagocytosis of C. albicans pseudohyphae by these two cell types. Intracellular killing of each of the four fungal forms was consistently and significantly more rapid by monocytes than by neutrophils. Neutrophils were unable to destroy ingested C. albicans pseudohyphae. These experiments suggest that the monocyte plays an important role in host defenses against fungal diseases and that the relative virulence of the pathogenic yeasts in human disease may be related to the ability of these organisms to survival after being ingested by circulating phagocytes.
研究了两种吞噬细胞对四种毒力不同的真菌形态进行吞噬和杀伤的动力学。人类单核细胞比人类中性粒细胞更快地摄取酿酒酵母、热带念珠菌和白色念珠菌的芽生孢子。这两种细胞类型对白色念珠菌假菌丝的吞噬速率没有差异。单核细胞对四种真菌形态中每一种的细胞内杀伤始终比中性粒细胞更快且更显著。中性粒细胞无法破坏摄取的白色念珠菌假菌丝。这些实验表明，单核细胞在宿主抗真菌疾病防御中起重要作用，并且致病性酵母在人类疾病中的相对毒力可能与这些生物体被循环吞噬细胞摄取后存活的能力有关。
