Wilson H D, Schedl H P
Am J Clin Nutr. 1987 Feb;45(2):437-42. doi: 10.1093/ajcn/45.2.437.
In rat with massive resection of mid-small intestine, calcium transport per segment, measured by in vivo perfusion 10 days after surgery, is decreased in duodenum and ileum but is the same in cecum and colon as compared with controls with transection and reanastomosis of mid-small intestine. To extend these findings, we measured balances of calcium, phosphorus, and fat from the 5th to 10th day after surgery and serum concentration of 1,25-dihydroxycholecalciferol on the 10th day after surgery in this experimental model. We found steatorrhea in the resected group, but balances of calcium and phosphorus and serum levels of 1,25-dihydroxycholecalciferol were the same in resected and control groups. We conclude that decreased transport defined by direct examination of membrane function may be undetectable when net transport is measured by balance. Calcium balance during early post-resection period provides no evidence for future calcium deficiency in this experimental model.
在进行中小肠大面积切除的大鼠中，术后10天通过体内灌注测量的每段钙转运量，十二指肠和回肠降低，但与中小肠横断并重新吻合的对照组相比，盲肠和结肠的钙转运量相同。为了扩展这些发现，我们在这个实验模型中测量了术后第5天至第10天的钙、磷和脂肪平衡，以及术后第10天的1,25 - 二羟胆钙化醇血清浓度。我们在切除组中发现了脂肪泻，但切除组和对照组的钙磷平衡以及1,25 - 二羟胆钙化醇血清水平相同。我们得出结论，当通过平衡测量净转运时，通过直接检查膜功能所定义的转运降低可能无法检测到。在切除后的早期阶段，钙平衡并未为该实验模型中未来的钙缺乏提供证据。
