El Said W, Awad S, Farid F, Maged Z, Fattah F A, El Maghraby M
Int Urol Nephrol. 1979;11(2):155-62. doi: 10.1007/BF02082236.
Twenty-one cases of acute glomerulonephritis in children with no previous history of renal disease were studied. Urinary infection with a rising titre of serum agglutinins against the organisms isolated from urine was found in 5 cases. No evidence of previous streptococcal infection was found in these cases. In the meantime all 8 cases with post-streptococcal glomerulonephritis remained without bacteriuria. In one case acute glomerulonephritis followed virus hepatitis, and in the remaining 7 cases the cause of glomerulonephritis was unknown. It is suggested that in predisposed patients the bacteria present in urinary infections might act as antigens starting immunologic reactions in the glomeruli, leading to glomerulonephritis. The final proof of this theory awaits immunofluorescence identification of these antigens in the glomeruli.
对21例既往无肾脏疾病史的儿童急性肾小球肾炎病例进行了研究。5例患者存在泌尿系统感染，其血清中针对从尿液中分离出的病原体的凝集素滴度升高。在这些病例中未发现先前有链球菌感染的证据。与此同时，所有8例链球菌感染后肾小球肾炎患者均无菌尿。1例急性肾小球肾炎继发于病毒性肝炎，其余7例肾小球肾炎病因不明。有人提出，在易感患者中，泌尿系统感染中存在的细菌可能作为抗原引发肾小球内的免疫反应，从而导致肾小球肾炎。这一理论的最终证据有待通过免疫荧光法对肾小球中的这些抗原进行鉴定。
