Greer F R, McCormick A
Am J Dis Child. 1987 Feb;141(2):179-83. doi: 10.1001/archpedi.1987.04460020069029.
It is reported that very-low-birth-weight (VLBW) infants with the complication of bronchopulmonary dysplasia (BPD) are at high risk for metabolic bone disease and growth retardation. In a prospective study, we compared growth and bone mineral content (BMC) during the first year of life in 16 VLBW infants with BPD and 16 VLBW control infants. The BPD and control groups were matched for gestational age (28.2 +/- 0.8 vs 28.4 +/- 1.2 weeks) and birth weight (986 +/- 158 vs 1037 +/- 147 g). Calcium, phosphorus, vitamin D, and energy intakes did not differ during the initial 60-day period of hospitalization. At 1 year of age, there were no significant differences in BMC (104.4 +/- 21.4 vs 109.7 +/- 19.2 mg/cm), weight (7440 +/- 1090 vs 7420 +/- 826 g), length (66.9 +/- 3.4 vs 67.7 +/- 3.0 cm), or head circumference (45.1 +/- 1.5 vs 44.0 +/- 1.0 cm) between BPD and control groups. In both groups bone mineralization was delayed compared to the intrauterine curve for BMC. Growth was also delayed compared to the growth curves of Babson for premature infants during the first year of life. We conclude that for our study population, factors other than the presence or absence of BPD are responsible for marked delays in bone mineralization and growth in VLBW premature infants.
据报道，患有支气管肺发育不良（BPD）并发症的极低出生体重（VLBW）婴儿患代谢性骨病和生长迟缓的风险很高。在一项前瞻性研究中，我们比较了16名患有BPD的VLBW婴儿和16名VLBW对照婴儿在出生后第一年的生长情况和骨矿物质含量（BMC）。BPD组和对照组在胎龄（28.2±0.8 vs 28.4±1.2周）和出生体重（986±158 vs 1037±147克）方面相匹配。在住院的最初60天内，钙、磷、维生素D和能量摄入量没有差异。在1岁时，BPD组和对照组在BMC（104.4±21.4 vs 109.7±19.2毫克/厘米）、体重（7440±1090 vs 7420±826克）、身长（66.9±3.4 vs 67.7±3.0厘米）或头围（45.1±1.5 vs 44.0±1.0厘米）方面没有显著差异。与宫内BMC曲线相比，两组的骨矿化均延迟。与巴布森早产婴儿第一年的生长曲线相比，生长也延迟了。我们得出结论，对于我们的研究人群，除了是否存在BPD之外的其他因素是导致VLBW早产婴儿骨矿化和生长明显延迟的原因。
