Department of Infectious Diseases, Baharloo Hospital, Railway Square, Tehran University of Medical Sciences, Tehran, Iran.
Health Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
J Prev Med Hyg. 2023 Nov 1;64(3):E298-E303. doi: 10.15167/2421-4248/jpmh2023.64.3.3032. eCollection 2023 Sep.
The severity of COVID-19 infection is affected by several risk factors such as Diabetes Mellitus (DM). The current study aimed to determine the effect of single-point HbA1c on the severity and mortality of hospitalized COVID-19 patients.
This cross-sectional study was conducted among hospitalized moderate and severe COVID-19 patients in Baharloo Hospital in Iran between December 23 and February 23rd, 2021. The patients have been diagnosed by Polymerase Chain Reaction (PCR) and Chest Computed Tomography (CT) imaging as COVID-19. Demographic data, clinical presentation, laboratory results, and treatments along with the HbA1c data were included.
165 COVID-19 cases were included in this study; 126 (76.4%) of which were severe cases. 89 (53.9%) patients were male, with a mean age of 59.89 ± 16.59 years. Severe COVID-19 patients were more prone to a longer hospital stay, and a higher level of inflammatory mediators, compared to the moderate COVID-19 patients (p < 0.05). No significant association was found between single point HbA1c, FBS, and severity and mortality of COVID-19 cases (p > 0.05).
Single point HbA1c was not a reliable mediator for the prediction of severity or death in hospitalized COVID-19 patients.
COVID-19 感染的严重程度受多种风险因素的影响，如糖尿病（DM）。本研究旨在确定单点 HbA1c 对住院 COVID-19 患者严重程度和死亡率的影响。
本横断面研究于 2021 年 12 月 23 日至 2 月 23 日在伊朗巴哈鲁医院对中度和重度 COVID-19 住院患者进行。患者通过聚合酶链反应（PCR）和胸部计算机断层扫描（CT）成像诊断为 COVID-19。纳入人口统计学数据、临床表现、实验室结果和治疗以及 HbA1c 数据。
本研究共纳入 165 例 COVID-19 病例，其中 126 例（76.4%）为重症病例。89 例（53.9%）为男性，平均年龄为 59.89 ± 16.59 岁。与中度 COVID-19 患者相比，重症 COVID-19 患者住院时间更长，炎症介质水平更高（p < 0.05）。单点 HbA1c、FBS 与 COVID-19 患者的严重程度和死亡率之间无显著相关性（p > 0.05）。
单点 HbA1c 不能可靠地预测住院 COVID-19 患者的严重程度或死亡。
