Xu Yingying, Goldenson Nicholas I, Prakash Shivaani, Augustson Erik M, Shiffman Saul
Juul Labs, Inc.
PinneyAssociates, Inc.
Exp Clin Psychopharmacol. 2024 Feb;32(1):3-15. doi: 10.1037/pha0000698. Epub 2023 Dec 21.
Observational studies show high rates of switching away from cigarettes among adult purchasers of JUUL-brand electronic nicotine delivery system (ENDS); data are needed to evaluate switching with JUUL in randomized general population trials. The association of ENDS flavor availability and switching is pertinent. This study assessed switch rates and smoking reduction among participants randomized to use JUUL in a choice of flavors or tobacco-only, compared to a condition provided smoking-cessation materials. U.S. adults who smoke cigarettes ( = 837; [] = 45.99 years [11.48]; 18.76 cigarettes/day [ = 7.86]; 50.2% female) from an address-based representative panel were randomized to receive JUUL for 6 months (5.0% nicotine; only Virginia Tobacco [ = 285] or choice of flavors [ = 281]), or smoking-cessation materials (quit advice [QA]; = 271). Self-reported past 30-day smoking and cigarette consumption were assessed at 1, 3, and 6 months. Repeated-measure regressions assessed differences in smoking outcomes between groups. Only 2% of participants were planning to quit smoking within 30 days. Across the 6-month intervention, participants randomized to JUUL (vs. QA) had 6.57-fold greater odds of reporting past 30-day switching (95% CI [3.72-11.63]). Participants in the JUUL (vs. QA) group smoked 27% fewer cigarettes/day versus baseline (Rate Ratio [95% CI] = 0.73 [0.68-0.77]). Over half (51.8%) of the Virginia Tobacco group used other flavors (36.7% nontobacco flavors), contaminating randomized flavor-conditions. JUUL flavor groups did not differ in smoking outcomes ( > .48). Use of JUUL products may support complete switching away from cigarettes, including among those not ready to quit smoking. Results suggest a preference for nontobacco-flavored ENDS among adults who smoke, although smoking outcomes did not differ by flavor. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
观察性研究表明，购买JUUL牌电子尼古丁传送系统（ENDS）的成年吸烟者中，改用其他产品的比例很高；需要通过随机对照的一般人群试验来评估使用JUUL后改用其他产品的情况。ENDS口味的可获得性与改用其他产品之间的关联很重要。本研究评估了在可选择口味或仅使用烟草口味的情况下，随机分配使用JUUL的参与者与接受戒烟材料的参与者相比，其改用其他产品的比例和吸烟量减少情况。从一个基于地址的代表性样本中招募了837名吸烟的美国成年人（年龄中位数[标准差]=45.99岁[11.48]；每天吸烟18.76支[标准差=7.86]；女性占50.2%），随机分为三组，分别接受为期6个月的JUUL（尼古丁含量5.0%；仅弗吉尼亚烟草口味组[285人]或可选择口味组[281人]），或戒烟材料（戒烟建议[QA]组；共271人）。在第1、3和6个月时评估自我报告的过去30天吸烟情况和香烟消费量。重复测量回归分析评估了各组吸烟结果的差异。只有2%的参与者计划在30天内戒烟。在为期6个月的干预期间，随机分配到JUUL组（与QA组相比）报告过去30天改用其他产品的几率高6.57倍（95%置信区间[3.72 - 11.63]）。JUUL组（与QA组相比）的参与者每天吸烟量比基线减少了27%（率比[95%置信区间]=0.73[0.68 - 0.77]）。超过一半（51.8%）的弗吉尼亚烟草口味组参与者使用了其他口味（36.7%为非烟草口味），这影响了随机分组的口味条件。JUUL不同口味组的吸烟结果没有差异（P>.48）。使用JUUL产品可能有助于完全戒除香烟，包括那些尚未准备好戒烟者。结果表明，吸烟的成年人对非烟草口味的ENDS有偏好，尽管不同口味的吸烟结果没有差异。（PsycInfo数据库记录（c）2024美国心理学会，保留所有权利）
