Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Breast Oncology, Peking University Cancer Hospital and Institute, Beijing, China,
Aerospace School of Clinical Medicine, Peking University, Beijing, China.
Oncol Res Treat. 2024;47(3):97-103. doi: 10.1159/000535649. Epub 2023 Dec 21.
Mucinous cystadenocarcinoma (MCA) of the breast is an extremely rare type of breast carcinoma. Since its biological characteristics, treatment options, and clinical outcomes are unclear, there is a lack of consensus regarding the optimal management of this disease. Thus, our single case report will aid our understanding of its natural history, prognostic factors, and treatment strategies.
We presented a 54-year-old woman with a case of advanced MCA of the breast accompanied by a huge breast mass, lymph node involvement, and distant bone metastases. We diagnosed primary breast MCA through clinical examination, imaging, and immunohistochemical assessments. Subsequently, the patient was treated with a regimen of nab-paclitaxel and bevacizumab, resulting in a significant clinical response. Progression-free survival was maintained during the 6-month follow-up period.
We present the first report worldwide of a rare case of MCA of the breast with a large local mass and bone metastases. Our report adds to the limited literature on this rare breast cancer subtype and highlights the importance of accurate diagnosis and appropriate management of aggressive breast tumors.
乳腺黏液囊腺癌（MCA）是一种极为罕见的乳腺癌。由于其生物学特性、治疗选择和临床结果尚不清楚，因此对于这种疾病的最佳治疗方法尚未达成共识。因此，我们的单一病例报告将有助于我们了解其自然病史、预后因素和治疗策略。
我们报告了一例 54 岁女性患有晚期乳腺 MCA，伴有巨大乳房肿块、淋巴结受累和远处骨转移。我们通过临床检查、影像学和免疫组织化学评估诊断为原发性乳腺 MCA。随后，患者接受了nab-紫杉醇和贝伐珠单抗治疗方案，取得了显著的临床反应。在 6 个月的随访期间，无疾病进展生存。
我们报告了首例伴有巨大局部肿块和骨转移的罕见乳腺 MCA 病例，这在世界范围内尚属首次。我们的报告增加了对这种罕见乳腺癌亚型的有限文献的了解，并强调了准确诊断和适当管理侵袭性乳腺肿瘤的重要性。
