Honma Naoko, Sakamoto Goi, Ikenaga Motoko, Kuroiwa Kojiro, Younes Mamoun, Takubo Kaiyo
Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
Arch Pathol Lab Med. 2003 Aug;127(8):1031-3. doi: 10.5858/2003-127-1031-MCOTBA.
We report a case of mucinous cystadenocarcinoma (MCA) of the breast in a 96-year-old woman. This is an extremely rare variant of primary breast carcinoma that bears a striking resemblance to MCAs of the ovary and pancreas. The macroscopic appearance and secretion pattern (cytologic findings) resembled cystic hypersecretory carcinoma. However, microscopically, the epithelial cells were quite different from those of cystic hypersecretory carcinoma. In the present study as well as in the literature, MCAs tend to occur more frequently in elderly women. Immunohistochemical findings suggest that they may develop independently of estrogenic stimulation. Although MCAs show high proliferative activity, the prognosis was favorable in the present case as well as in the reported cases. Because MCAs appear to have a distinct pathogenesis and biologic behavior, they should be distinguished from ordinary mucinous carcinomas, cystic hypersecretory carcinomas, and carcinomas of other histologic subtypes.
我们报告了一例96岁女性乳腺黏液性囊腺癌（MCA）。这是原发性乳腺癌一种极为罕见的变异类型，与卵巢和胰腺的黏液性囊腺癌极为相似。其大体外观和分泌模式（细胞学表现）类似于囊性高分泌性癌。然而，在显微镜下，上皮细胞与囊性高分泌性癌的上皮细胞有很大不同。在本研究以及文献中，黏液性囊腺癌往往更常见于老年女性。免疫组化结果提示它们可能独立于雌激素刺激而发生。尽管黏液性囊腺癌显示出较高的增殖活性，但在本病例以及报道的病例中预后良好。由于黏液性囊腺癌似乎具有独特的发病机制和生物学行为，因此应将其与普通黏液腺癌、囊性高分泌性癌以及其他组织学亚型的癌相区分。
