Key Laboratory of High Efficiency and Clean Mechanicalanufacture of Ministry of Education, School of Mechanical Engineering, Shandong University, Jinan 250061, PR China; Key National Demonstration Center for Experimental Mechanical Engineering Education, Shandong University, Jinan 250061, PR China.
Key Laboratory of High Efficiency and Clean Mechanicalanufacture of Ministry of Education, School of Mechanical Engineering, Shandong University, Jinan 250061, PR China; Key National Demonstration Center for Experimental Mechanical Engineering Education, Shandong University, Jinan 250061, PR China.
Acta Biomater. 2024 Feb;175:76-105. doi: 10.1016/j.actbio.2023.12.024. Epub 2023 Dec 19.
The lubrication modification of biomedical devices significantly enhances the functionality of implanted interventional medical devices, thereby providing additional benefits for patients. Polymer brush coating provides a convenient and efficient method for surface modification while ensuring the preservation of the substrate's original properties. The current research has focused on a "trial and error" method to finding polymer brushes with superior lubricity qualities, which is time-consuming and expensive, as obtaining effective and long-lasting lubricity properties for polymer brushes is difficult. This review summarizes recent research advances in the biomedical field in the design, material selection, preparation, and characterization of lubricating and antifouling polymer brushes, which follow the polymer brush development process. This review begins by examining various approaches to polymer brush design, including molecular dynamics simulation and machine learning, from the fundamentals of polymer brush lubrication. Recent advancements in polymer brush design are then synthesized and potential avenues for future research are explored. Emphasis is placed on the burgeoning field of zwitterionic polymer brushes, and highlighting the broad prospects of supramolecular polymer brushes based on host-guest interactions in the field of self-repairing polymer brush applications. The review culminates by providing a summary of methodologies for characterizing the structural and functional attributes of polymer brushes. It is believed that a development approach for polymer brushes based on "design-material selection-preparation-characterization" can be created, easing the challenge of creating polymer brushes with high-performance lubricating qualities and enabling the on-demand creation of coatings. STATEMENT OF SIGNIFICANCE: Biomedical devices have severe lubrication modification needs, and surface lubrication modification by polymer brush coating is currently the most promising means. However, the design and preparation of polymer brushes often involves "iterative testing" to find polymer brushes with excellent lubrication properties, which is both time-consuming and expensive. This review proposes a polymer brush development process based on the "design-material selection-preparation-characterization" strategy and summarizes recent research advances and trends in the design, material selection, preparation, and characterization of polymer brushes. This review will help polymer brush researchers by alleviating the challenges of creating polymer brushes with high-performance lubricity and promises to enable the on-demand construction of polymer brush lubrication coatings.
生物医学设备的润滑改性显著增强了植入式介入医疗器械的功能，从而为患者带来了额外的益处。聚合物刷涂层提供了一种方便、高效的表面改性方法，同时确保了基底原有性能的保留。目前的研究集中在寻找具有优异润滑性的聚合物刷的“试错”方法上，这既耗时又昂贵，因为获得具有有效和持久润滑性的聚合物刷是困难的。
本综述总结了近年来在设计、材料选择、制备和表征润滑和抗污聚合物刷方面的生物医学领域的研究进展，这些进展遵循聚合物刷的发展过程。本综述首先从聚合物刷润滑的基础出发，研究了聚合物刷设计的各种方法，包括分子动力学模拟和机器学习。然后，综合了聚合物刷设计的最新进展，并探讨了未来的研究方向。重点介绍了两性离子聚合物刷这一新兴领域，并强调了基于主客体相互作用的超分子聚合物刷在自修复聚合物刷应用领域的广阔前景。最后，综述了聚合物刷结构和功能特性表征方法的总结。
相信可以创建一种基于“设计-材料选择-制备-表征”的聚合物刷发展方法，从而缓解具有高性能润滑特性的聚合物刷的设计和制备难题，实现按需构建涂层。
