Centro Universitário do Espírito Santo (UNESC), Espírito Santo.
Department of Health Sciences and Pediatric Dentistry, at the Piracicaba Dental School, University of Campinas, Areião, Piracicaba, São Paulo, Brazil.
Pediatr Dent. 2023 Nov 15;45(6):524-530.
To evaluate, in vitro, whether the presence of the acquired pellicle (AP) interferes with the effect of 38 percent silver diamine fluoride (SDF) on the inhibition or progression of carious dentin. Carious dentin specimens were divided into groups: C-no treatment control; FV-fluoride varnish; AP-acquired pellicle formation; SDF only, and APSDF-SDF plus acquired pellicle formation. After AP formation (AP and APSDF groups), all groups were subjected to pH cycling. Dentin mineral gain or loss was quantified using surface microhardness (SM). Concentrations of fluoride calcium (CaF₂) and fluorapatite (FAp) fluoride retained in dentin and fluoride concentrations in de- and remineralizing solutions were determined. Groups AP, FV, SDF, and APSDF showed reduced demineralization compared with the C group, but the AP group showed greater surface loss than the fluoridated groups. Groups FV, SDF, and APSDF showed greater mineral recovery than C and AP groups (P<0.05), but no differences were observed between the FV, SDF, and APSDF groups (P>0.05). The retained CaF₂ and FAp were greater in the groups treated with fluoride, but there was no difference between the SDF and APSDF groups. The presence of the acquired pellicle reduced the progression of carious dentin lesion but did not influence its remineralization when associated with silver diamine fluoride.
为了评估获得性薄膜（AP）的存在是否会影响 38% 氟化银（SDF）对龋齿牙本质抑制或进展的作用，我们在体外进行了研究。将龋齿牙本质标本分为以下几组：C-无处理对照组；FV-氟化物涂料；AP-获得性薄膜形成；SDF 仅处理组，和 APSDF-SDF 加获得性薄膜形成组。在形成获得性薄膜（AP 和 APSDF 组）后，所有组均进行 pH 循环。使用表面显微硬度（SM）定量测量牙本质矿物质的获得或损失。检测牙本质中保留的氟钙（CaF₂）和氟磷灰石（FAp）氟化物浓度以及脱矿和再矿化溶液中的氟化物浓度。与 C 组相比，AP 组、FV 组、SDF 组和 APSDF 组的脱矿作用明显减少，但 AP 组的表面损失大于氟化物处理组。FV 组、SDF 组和 APSDF 组的矿物质恢复量大于 C 组和 AP 组（P<0.05），但 FV 组、SDF 组和 APSDF 组之间无差异（P>0.05）。用氟化物处理的各组中保留的 CaF₂和 FAp 更多，但 SDF 组和 APSDF 组之间无差异。获得性薄膜的存在减少了龋齿牙本质病变的进展，但与银胺氟化物联合使用时并不影响其再矿化。
