Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
Wallenberg Centre for Molecular Medicine, Linköping University, Linköping, Sweden.
BMC Gastroenterol. 2023 Dec 21;23(1):454. doi: 10.1186/s12876-023-03093-8.
Liver cirrhosis, the advanced stage of many chronic liver diseases, is associated with escalated risks of liver-related complications like decompensation and hepatocellular carcinoma (HCC). Morbidity and mortality in cirrhosis patients are linked to portal hypertension, sarcopenia, and hepatocellular carcinoma. Although conventional cirrhosis management centered on treating complications, contemporary approaches prioritize preemptive measures. This study aims to formulate novel blood- and imaging-centric methodologies for monitoring liver cirrhosis patients.
In this prospective study, 150 liver cirrhosis patients will be enrolled from three Swedish liver clinics. Their conditions will be assessed through extensive blood-based markers and magnetic resonance imaging (MRI). The MRI protocol encompasses body composition profile with Muscle Assement Score, portal flow assessment, magnet resonance elastography, and a abbreviated MRI for HCC screening. Evaluation of lifestyle, muscular strength, physical performance, body composition, and quality of life will be conducted. Additionally, DNA, serum, and plasma biobanking will facilitate future investigations.
The anticipated outcomes involve the identification and validation of non-invasive blood- and imaging-oriented biomarkers, enhancing the care paradigm for liver cirrhosis patients. Notably, the temporal evolution of these biomarkers will be crucial for understanding dynamic changes.
Clinicaltrials.gov, registration identifier NCT05502198. Registered on 16 August 2022. Link: https://classic.
gov/ct2/show/NCT05502198 .
肝硬化是许多慢性肝病的晚期阶段，与肝功能失代偿和肝细胞癌（HCC）等肝脏相关并发症的风险增加有关。肝硬化患者的发病率和死亡率与门静脉高压、肌肉减少症和肝细胞癌有关。虽然传统的肝硬化管理以治疗并发症为中心，但现代方法侧重于预防措施。本研究旨在为监测肝硬化患者制定新的血液和成像为中心的方法。
在这项前瞻性研究中，将从瑞典的三家肝脏诊所招募 150 名肝硬化患者。他们的病情将通过广泛的血液标志物和磁共振成像（MRI）进行评估。MRI 方案包括肌肉评估评分的身体成分谱、门脉血流评估、磁共振弹性成像和用于 HCC 筛查的简化 MRI。将评估生活方式、肌肉力量、身体表现、身体成分和生活质量。此外，还将进行 DNA、血清和血浆生物库建设，以促进未来的研究。
预期的结果涉及识别和验证非侵入性的血液和成像为导向的生物标志物，从而改善肝硬化患者的护理模式。值得注意的是，这些生物标志物的时间演变对于了解动态变化至关重要。
Clinicaltrials.gov，注册标识符 NCT05502198。于 2022 年 8 月 16 日注册。链接：https://classic.
临床试验.gov/ct2/show/NCT05502198。
