25 年来，前列腺癌的发病率显著降低，存活率提高。
Significantly reduced incidence and improved survival from prostate cancer over 25 years.
机构信息
Department of Nursing, Universitat de Girona, 17003, Girona, Spain.
Epidemiology Unit and Girona Cancer Registry, Institut Català d'Oncologia, Pla Director d'Oncologia, Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta (IDIBGI), 17004, Girona, Spain.
出版信息
BMC Public Health. 2023 Dec 21;23(1):2552. doi: 10.1186/s12889-023-17440-7.
BACKGROUND
Prostate cancer (PCa) was the second most frequent cancer and the fifth leading cause of cancer death among men in 2020. The aim of this study was to analyze trends in the incidence, mortality and survival of PCa in Girona, Spain, over 25 years.
METHODS
Population-based study of PCa collected in the Girona Cancer Registry, 1994-2018. Age-adjusted incidence and mortality rates were calculated per 100,000 men-year. Joinpoint regression models were used for trends, calculating the annual percentage changes (APC). Observed and net survival were analyzed using Kaplan-Meier and Pohar-Perme estimations, respectively.
RESULTS
A total of 9,846 cases of PCa were registered between 1994-2018. The age-adjusted incidence and mortality rates were 154.7 (95%CI: 151.7 157.8) and 38.9 (95%CI: 37.3 -40.6), respectively. An increased incidence of 6.2% was observed from 1994 to 2003 (95%CI: 4.4 -8.1), and a decrease of -2.7% (95%CI: -3.5 -;-1.9) between 2003 and 2018. Mortality APC was -2.6% (95%CI: -3.3 --2.0). Five-year observed and net survival were 72.8% (95%CI: 71.8 - 73.7) and 87.2% (95%CI: 85.9 - 88.4), respectively. Five-year net survival increased over time from 72.9% (1994-1998) to 91.3% (2014-2018).
CONCLUSIONS
The analyses show a clear reduction in PCa incidence rates from 2003 on, along with an increase in overall survival when comparing the earlier period with more recent years.
背景
前列腺癌（PCa）是 2020 年男性中第二常见的癌症和第五大癌症死亡原因。本研究旨在分析 25 年来西班牙赫罗纳地区 PCa 的发病率、死亡率和生存率趋势。
方法
对 1994 年至 2018 年赫罗纳癌症登记处收集的 PCa 进行基于人群的研究。每 10 万名男性年计算年龄调整后的发病率和死亡率。使用 Joinpoint 回归模型分析趋势，计算年百分比变化（APC）。使用 Kaplan-Meier 和 Pohar-Perme 估计分别分析观察生存率和净生存率。
结果
1994 年至 2018 年间共登记了 9846 例 PCa 病例。年龄调整后的发病率和死亡率分别为 154.7（95%CI：151.7-157.8）和 38.9（95%CI：37.3-40.6）。1994 年至 2003 年，发病率增加了 6.2%（95%CI：4.4-8.1），2003 年至 2018 年，发病率下降了-2.7%（95%CI：-3.5--1.9）。死亡率的 APC 为-2.6%（95%CI：-3.3--2.0）。5 年观察生存率和净生存率分别为 72.8%（95%CI：71.8-73.7）和 87.2%（95%CI：85.9-88.4）。5 年净生存率随着时间的推移而增加，从 1994 年至 1998 年的 72.9%增加到 2014 年至 2018 年的 91.3%。
结论
分析表明，2003 年以来 PCa 的发病率明显下降，与早期相比，近年来总体生存率有所提高。
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