Yangtze University, Jingzhou, China.
Yangtze University College of Arts and Sciences, Jingzhou, China.
Int Wound J. 2024 Apr;21(4):e14562. doi: 10.1111/iwj.14562. Epub 2023 Dec 21.
Burn injuries result in localised tissue damage and precipitate systemic responses; routine clinical treatments, which typically include metabolic nutritional support and anti-infection therapies, do not yield optimal outcomes. Therefore, we aimed to systematically evaluate the effects of ulinastatin on wound infection and healing in patients with burns to provide reliable evidence-based recommendations for burn treatment. An electronic search of the Web of Science, PubMed, Cochrane Library, Embase, Wanfang, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure databases, supplemented by manual searches, was conducted from database inception to October 2023 to collect randomised controlled trials (RCTs) assessing the efficacy of ulinastatin for the treatment of burns. Two researchers screened all retrieved articles according to the inclusion and exclusion criteria; the included studies were evaluated for quality, and the relevant data were extracted. Stata 17.0 software was employed for data analysis. Overall, 8 RCTs with 803 patients were included, with 404 and 399 in the ulinastatin and conventional treatment groups, respectively. The analysis revealed that wound infections (odds ratio [OR] = 0.08, 95% CI: 0.02-0.35, p = 0.001) and complications (OR = 0.21, 95% CI: 0.10-0.42, p < 0.001) were significantly lower, and wound healing time (standardised mean differences [SMD] = -1.31, 95% CI: -2.05 to -0.57, p = 0.001) was significantly shorter, in the ulinastatin groups than in the control group. This meta-analysis revealed that ulinastatin can effectively reduce the incidence of wound infections and complications and significantly shorten the duration of wound healing in patients with burns, thereby promoting early recovery in these patients.
烧伤会导致局部组织损伤，并引发全身性反应；常规的临床治疗方法，通常包括代谢营养支持和抗感染治疗，并不能取得最佳的效果。因此，我们旨在系统评估乌司他丁对烧伤患者伤口感染和愈合的影响，为烧伤治疗提供可靠的循证推荐。从数据库建立到 2023 年 10 月，我们通过电子检索 Web of Science、PubMed、Cochrane Library、Embase、万方、中国生物医学文献数据库和中国国家知识基础设施数据库，并辅以手动检索，收集评估乌司他丁治疗烧伤疗效的随机对照试验（RCT）。两名研究人员根据纳入和排除标准筛选所有检索到的文章；评估纳入研究的质量，并提取相关数据。采用 Stata 17.0 软件进行数据分析。总体而言，纳入了 8 项 RCT 共 803 名患者，乌司他丁组和常规治疗组分别有 404 名和 399 名患者。分析结果显示，乌司他丁组的伤口感染（比值比 [OR] = 0.08，95%置信区间：0.02-0.35，p = 0.001）和并发症（OR = 0.21，95%置信区间：0.10-0.42，p < 0.001）显著降低，伤口愈合时间（标准化均数差 [SMD] = -1.31，95%置信区间：-2.05 至 -0.57，p = 0.001）显著缩短。这项荟萃分析表明，乌司他丁能有效降低烧伤患者伤口感染和并发症的发生率，并显著缩短伤口愈合时间，从而促进这些患者的早期康复。
