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局部麻醉药控释系统在疼痛管理中的应用进展。

Advances in the use of local anesthetic extended-release systems in pain management.

机构信息

Department of Anesthesiology, Xiangya Hospital, Central South University, Changsha, China.

National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.

出版信息

Drug Deliv. 2024 Dec;31(1):2296349. doi: 10.1080/10717544.2023.2296349. Epub 2023 Dec 21.

DOI:10.1080/10717544.2023.2296349
PMID:38130151
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10763865/
Abstract

Pain management remains among the most common and largely unmet clinical problems today. Local anesthetics play an indispensable role in pain management. The main limitation of traditional local anesthetics is the limited duration of a single injection. To address this problem, catheters are often placed or combined with other drugs in clinical practice to increase the time that local anesthetics act. However, this method does not meet the needs of clinical analgesics. Therefore, many researchers have worked to develop local anesthetic extended-release types that can be administered in a single dose. In recent years, drug extended-release systems have emerged dramatically due to their long duration and efficacy, providing more possibilities for the application of local anesthetics. This paper summarizes the types of local anesthetic drug delivery systems and their clinical applications, discusses them in the context of relevant studies on local anesthetics, and provides a summary and outlook on the development of local anesthetic extended-release agents.

摘要

疼痛管理仍然是当今最常见且在很大程度上未得到满足的临床问题之一。局部麻醉药在疼痛管理中起着不可或缺的作用。传统局部麻醉药的主要局限性是单次注射的持续时间有限。为了解决这个问题，导管经常被放置或与其他药物结合在临床实践中，以增加局部麻醉药的作用时间。然而，这种方法并不能满足临床镇痛的需求。因此，许多研究人员致力于开发可单次给药的局部麻醉药长效释放剂型。近年来，由于其长效性和疗效，药物长效释放系统迅速出现，为局部麻醉药的应用提供了更多的可能性。本文总结了局部麻醉药给药系统的类型及其临床应用，并结合局部麻醉药的相关研究进行了讨论，对局部麻醉药长效释放制剂的发展进行了总结和展望。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2994/10763865/dc87c4671536/IDRD_A_2296349_F0010_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2994/10763865/fd87945b2d48/IDRD_A_2296349_UF0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2994/10763865/2d4a33e30b4e/IDRD_A_2296349_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2994/10763865/b722c044029d/IDRD_A_2296349_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2994/10763865/3cc167cb3efa/IDRD_A_2296349_F0003_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2994/10763865/9541e8f88e3e/IDRD_A_2296349_F0004_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2994/10763865/3cf3a0f8069b/IDRD_A_2296349_F0005_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2994/10763865/c3308eb79a22/IDRD_A_2296349_F0006_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2994/10763865/a62e92ca3ff0/IDRD_A_2296349_F0007_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2994/10763865/a0e2360eefe9/IDRD_A_2296349_F0008_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2994/10763865/cf3b6b8a1ba7/IDRD_A_2296349_F0009_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2994/10763865/dc87c4671536/IDRD_A_2296349_F0010_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2994/10763865/fd87945b2d48/IDRD_A_2296349_UF0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2994/10763865/2d4a33e30b4e/IDRD_A_2296349_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2994/10763865/b722c044029d/IDRD_A_2296349_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2994/10763865/3cc167cb3efa/IDRD_A_2296349_F0003_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2994/10763865/9541e8f88e3e/IDRD_A_2296349_F0004_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2994/10763865/3cf3a0f8069b/IDRD_A_2296349_F0005_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2994/10763865/c3308eb79a22/IDRD_A_2296349_F0006_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2994/10763865/a62e92ca3ff0/IDRD_A_2296349_F0007_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2994/10763865/a0e2360eefe9/IDRD_A_2296349_F0008_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2994/10763865/cf3b6b8a1ba7/IDRD_A_2296349_F0009_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2994/10763865/dc87c4671536/IDRD_A_2296349_F0010_C.jpg

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本文引用的文献

[1]
Characterization of exparel bupivacaine multivesicular liposomes.

Int J Pharm. 2023-5-25

[2]
The use of liposomal bupivacaine in fracture surgery: a review.

J Orthop Surg Res. 2023-4-1

[3]
PALLIATIVE TREATMENT OF INTRACTABLE CANCER PAIN.

Acta Clin Croat. 2022-9

[4]
Swelling of Multilayered Calcium Alginate Microspheres for Drug-Loaded Dressing Induced Rapid Lidocaine Release for Better Pain Control.

Am J Chin Med. 2022

[5]
Preparation and Characterization of Lidocaine-Loaded, Microemulsion-Based Topical Gels.

Iran J Pharm Res. 2022-1-12

[6]
Nanoparticle classification, physicochemical properties, characterization, and applications: a comprehensive review for biologists.

J Nanobiotechnology. 2022-6-7

[7]
PLGA-based microspheres containing ropivacaine and betamethasone for sciatic nerve block in mice.

Pharm Dev Technol. 2022-6

[8]
SABER-Bupivacaine Reduces Postoperative Pain and Opioid Consumption After Arthroscopic Subacromial Decompression: A Randomized, Placebo-Controlled Trial.

J Am Acad Orthop Surg Glob Res Rev. 2022-5-1

[9]
Thermosensitive injectable graphene oxide/chitosan-based nanocomposite hydrogels for controlling the in vivo release of bupivacaine hydrochloride.

Int J Pharm. 2022-6-10

[10]
[Liposomal bupivacaine-No breakthrough in postoperative pain management].

Anaesthesiologie. 2022-7

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