Kim Ye Kyung, Park Peong Gang
Department of Pediatrics, Konkuk University Medical Center, Seoul, Korea.
Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Korea.
Transl Pediatr. 2023 Nov 28;12(11):2020-2029. doi: 10.21037/tp-23-361. Epub 2023 Nov 15.
Although various childhood illnesses are known to influence growth status, the impact of urinary tract infections (UTI) on subsequent childhood growth remains unclear. This study was conducted to examine the association between UTI during infancy and growth status at 30-36 months.
Nationwide population-based matched cohort study was done using data from the Korean National Health Insurance System (NHIS) and the Korean National Health Screening Program for Infants and Children (NHSPIC) between January 2018 and December 2020. Height and weight standard deviation scores (SDSs) at the fourth Korean NHSPIC conducted at 30-36 months were compared between children who experienced UTI during infancy and age- and sex-matched controls. We used weighted multiple linear regression analysis with inverse probability of treatment weighting (IPTW) and identified differences between the two groups using β coefficient with corresponding 95% confidence intervals (CIs).
We analyzed 84,519 children diagnosed with UTI during infancy and 84,519 age- and sex-matched controls. The height SDS between children who experienced UTI and the control group was not statistically different (β coefficient for height SDS, -0.0034; 95% CI: -0.0121 to 0.0054). However, the body mass index (BMI) SDS was significantly higher in children who had experienced UTI (β coefficient for BMI SDS, 00426; 95% CI: 0.0304 to 0.0547). Subgroup and sensitivity analysis showed consistent results.
Our findings suggest that a history of UTI during infancy is associated with high BMI measured at 30-36 months.
尽管已知各种儿童疾病会影响生长状况，但尿路感染（UTI）对儿童后续生长的影响仍不明确。本研究旨在探讨婴儿期UTI与30至36个月时生长状况之间的关联。
利用2018年1月至2020年12月期间韩国国民健康保险系统（NHIS）和韩国婴幼儿国家健康筛查计划（NHSPIC）的数据，进行了一项基于全国人群的匹配队列研究。比较了婴儿期经历过UTI的儿童与年龄和性别匹配的对照组在韩国NHSPIC第四次检查时（30至36个月）的身高和体重标准差分数（SDS）。我们使用加权多重线性回归分析及治疗权重的逆概率（IPTW），并通过β系数及相应的95%置信区间（CI）确定两组之间的差异。
我们分析了84,519名在婴儿期被诊断为UTI的儿童和84,519名年龄和性别匹配的对照组。经历过UTI的儿童与对照组之间的身高SDS无统计学差异（身高SDS的β系数为-0.0034；95%CI：-0.0121至0.0054）。然而，经历过UTI的儿童的体重指数（BMI）SDS显著更高（BMI SDS的β系数为0.0426；95%CI：0.0304至0.0547）。亚组和敏感性分析显示了一致的结果。
我们的研究结果表明，婴儿期UTI病史与30至36个月时测量的高BMI相关。
